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1. (WO1998053104) DETECTION OF RETROVIRAL SUBTYPES BASED UPON ENVELOPE SPECIFIC SEQUENCES

Pub. No.:    WO/1998/053104    International Application No.:    PCT/GB1998/001428
Publication Date: Fri Nov 27 00:59:59 CET 1998 International Filing Date: Tue May 19 01:59:59 CEST 1998
IPC: C07K 14/15
C12Q 1/70
G01N 33/569
Applicants: MEDICAL RESEARCH COUNCIL
STOYE, Jonathan, Paul
WEISS, Robin, Anthony
Inventors: STOYE, Jonathan, Paul
WEISS, Robin, Anthony
Title: DETECTION OF RETROVIRAL SUBTYPES BASED UPON ENVELOPE SPECIFIC SEQUENCES
Abstract:
The present invention is based upon the finding that porcine endogenous retroviruses exist in two different subtypes, which we have termed PERV-A and PERV-B. The differences are reflected in sequence divergence in the envelope genes, and these differences may be used to provide nucleic acid and antibody probes which can distinguish between the two subtypes. This allows patterns of subtype transmission between cells, particularly porcine to human cells, to be monitored.