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1. (WO1998053091) SCREENING ASSAYS FOR AGENTS THAT ALTER INHIBITOR OF APOPTOSIS (IAP) PROTEIN REGULATION OF CASPASE ACTIVITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/053091 International Application No.: PCT/US1998/007357
Publication Date: 26.11.1998 International Filing Date: 10.04.1998
Chapter 2 Demand Filed: 01.12.1998
IPC:
G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
THE BURNHAM INSTITUTE [US/US]; 10901 North Torrey Pines Road La Jolla, CA 92037, US
Inventors:
REED, John, C.; US
DEVERAUX, Quinn; US
SALVESEN, Guy, S.; US
TAKAHASHI, Ryosuke; JP
ROY, Natalie; US
Agent:
GASHLER, Andrea, L. ; Campbell & Flores LLP Suite 700 4370 La Jolla Village Drive San Diego, CA 92122, US
Priority Data:
08/862,08722.05.1997US
Title (EN) SCREENING ASSAYS FOR AGENTS THAT ALTER INHIBITOR OF APOPTOSIS (IAP) PROTEIN REGULATION OF CASPASE ACTIVITY
(FR) TECHNIQUE DE CRIBLAGE D'AGENTS MODIFIANT LA REGULATION DE L'ACTIVITE DE LA CASPASE, REGULATION DANS LAQUELLE INTERVIENT LA PROTEINE INHIBITRICE DE L'APOPTOSE (IAP)
Abstract:
(EN) The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP and a caspase. In addition, the invention provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP and further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. In addition, the invention provides methods of modulating the ability of a population of cells to survive $i(ex vivo) by contacting the cells with an agent that alters the caspase inhibitory activity of an IAP in the cells.
(FR) Cette invention a trait à une interaction entre une protéine inhibitrice de l'apoptose (IAP) et des membres de la famille caspase appartenant à la famille des protéases de la mort cellulaire, l'IAP régulant l'activité des caspases. L'invention porte sur des techniques de criblage aux fins de l'identification d'agents modifiant l'association spécifique d'une IAP et d'une caspase. Elle concerne, de surcroît, d'une part, des méthodes d'identification d'agents modulant l'activité d'une caspase en présence d'une IAP et régulant l'activation d'une pro-caspase et, d'autre part, des méthodes visant à atténuer la gravité d'un état pathologique en administrant au patient souffrant de cet état pathologique un agent qui modifie l'activité de l'IAP, en l'occurrence, son activité inhibitrice à l'encontre de la caspase. Cette invention porte, en outre, sur des techniques permettant de moduler les capacités d'une population cellulaire à survivre $i(ex vivo) en mettant en contact ces cellules avec un agent modifiant l'activité inhibitrice de l'IAP à l'encontre de la caspase dans lesdites cellules.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0983376JP2006204308JP2001510345 CA2289972AU1998068988