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1. (WO1998053078) PRODUCTION OF ATTENUATED PARAINFLUENZA VIRUS VACCINES FROM CLONED NUCLEOTIDE SEQUENCES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/053078 International Application No.: PCT/US1998/010551
Publication Date: 26.11.1998 International Filing Date: 22.05.1998
Chapter 2 Demand Filed: 10.12.1998
IPC:
A61K 39/00 (2006.01) ,C07K 14/115 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
115
Paramyxoviridae, e.g. parainfluenza virus
Applicants:
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE DEPARTMENT OF HEALTH AND HUMANSERVICES [US/US]; Box OTT Bethesda, MD 20892, US (AllExceptUS)
MURPHY, Brian, R. [US/US]; US (UsOnly)
COLLINS, Peter, L. [US/US]; US (UsOnly)
DURBIN, Anna, P. [US/US]; US (UsOnly)
SKIADOPOULOS, Mario, H. [US/US]; US (UsOnly)
TAO, Tao [CN/US]; US (UsOnly)
Inventors:
MURPHY, Brian, R.; US
COLLINS, Peter, L.; US
DURBIN, Anna, P.; US
SKIADOPOULOS, Mario, H.; US
TAO, Tao; US
Agent:
KING, Jeffrey, J. ; Townsend and Townsend and Crew LLP 8th floor Two Embarcadero Center San Francisco, CA 94111-3834, US
Priority Data:
60/047,57523.05.1997US
60/059,38519.09.1997US
Title (EN) PRODUCTION OF ATTENUATED PARAINFLUENZA VIRUS VACCINES FROM CLONED NUCLEOTIDE SEQUENCES
(FR) PRODUCTION DE VACCINS A VIRUS PARA-INFLUENZA ATTENUE A PARTIR DE SEQUENCES NUCLEOTIDIQUES CLONEES.
Abstract:
(EN) Isolated polynucleotide molecules provide recombinant PIV genomes and antigenomes for production of recombinant PIV vaccines. The recombinant genome or antigenome can be expressed with a nucleoprotein (N), phosphoprotein (P), and a large (L) polymerase protein to produce isolated infectious PIV particles. The recombinant PIV genome and antigenome can be modified to produce desired changes, for example to incorporate attenuating mutations from biologically derived PIV mutants or to create chimeric PIV clones, to generate attenuated, immunogenic viruses for vaccine use.
(FR) L'invention concerne des molécules isolées de polynucléotides permettant d'obtenir des génomes et des antigénomes recombinés du virus para-influenza (PIV), lesquels permettent de produire des vaccins contre le PIV recombiné. Le génome ou l'antigénome recombiné peut être exprimé à l'aide d'une nucléoprotéine (N), d'une phosphoprotéine (P), et d'une protéine de polymérase (L) de grande taille pour produire des particules infectieuses isolées du PIV. Le génome et l'antigénome recombinés du PIV peuvent être modifiés pour produire les changements voulus, par exemple pour intégrer des mutations d'atténuation provenant de mutants du PIV dérivés biologiquement ou pour créer des clones chimères du PIV, ou pour générer des virus immunogènes atténués pouvant faire l'objet de vaccins.
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Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1020010012893EP0994949ES2362564JP2002502241 CN1306575CA2291216
AU1998077977