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1. (WO1998053077) LIVE ATTENUATED VIRUS VACCINES FOR EQUINE ENCEPHALITIS VIRUSES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/053077 International Application No.: PCT/US1998/010645
Publication Date: 26.11.1998 International Filing Date: 20.05.1998
IPC:
A61K 39/00 (2006.01) ,C07K 14/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
18
Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
Applicants:
WALTER REED ARMY INSTITUTE OF RESEARCH [--/US]; Dept. of the Army Washington, DC 20307, US (AllExceptUS)
PARKER, Michael, D. [US/US]; US (UsOnly)
SMITH, Jonathan, F. [US/US]; US (UsOnly)
CRISE, Bruce, J. [US/US]; US (UsOnly)
OBERSTE, Mark, Steve [US/US]; US (UsOnly)
SCHMURA, Shannon, M. [US/US]; US (UsOnly)
Inventors:
PARKER, Michael, D.; US
SMITH, Jonathan, F.; US
CRISE, Bruce, J.; US
OBERSTE, Mark, Steve; US
SCHMURA, Shannon, M.; US
Agent:
HARRIS, Charles, H.; United States Army Medical Research and Materiel Command 504 Scott Street Fort Detrick, MD 21702, US
Priority Data:
08/991,84016.12.1997US
60/047,16220.05.1997US
60/053,65224.07.1997US
Title (EN) LIVE ATTENUATED VIRUS VACCINES FOR EQUINE ENCEPHALITIS VIRUSES
(FR) VACCINS ANTIVIRAUX VIVANTS ATTENUES CONTRE LES VIRUS DE L'ENCEPHALITE EQUINE
Abstract:
(EN) cDNAs coding for an infectious Western Equine Encephalitis virus (WEE) and infectious Venezuelan Equine Encephalitis virus variant IE (VEE IE) are disclosed in addition to cDNA coding for the structural proteins of Venezuelan Equine Encephalitis virus variant IIIA (VEE IIIA). Novel attenuating mutations of WEE and VEE IE and their uses are described. Also disclosed are attenuated chimearic alphaviruses and their uses.
(FR) La présente invention concerne des ADNc codant un virus infectieux de l'encéphalite équine de l'Ouest (WEE) et la variante IE (VEE EI) du virus infectieux de l'encéphalite équine du Vénézuela, ainsi que des ADNc codant les protéines structurelles de la variante IIIA (VEE IIIA) du virus de l'encéphalite équine du Vénézuela. L'invention se rapporte à de nouvelles mutations atténuantes du WEE et du VEE IE et à leurs utilisations. L'invention se rapporte enfin à des alphavirus chimères atténués et à leurs utilisations.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998075018