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1. (WO1998053072) THE PRODUCTION OF HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/053072 International Application No.: PCT/KR1998/000125
Publication Date: 26.11.1998 International Filing Date: 21.05.1998
IPC:
C07K 14/535 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
53
Colony-stimulating factor (CSF)
535
Granulocyte CSF; Granulocyte-macrophage CSF
Applicants:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR/KR]; P.O. Box 115 Yusong Taejon 305-333, KR (AllExceptUS)
JEIL PHARMACEUTICAL CO., LTD. [KR/KR]; 745-5, Banpo-dong Seocho-ku Seoul 137-040, KR (AllExceptUS)
JUN, Hyung-Kyun [KR/KR]; KR (UsOnly)
CHOI, Bong-Woong [KR/KR]; KR (UsOnly)
LEE, Young-Ik [KR/KR]; KR (UsOnly)
SOHN, Mi-Jin [KR/KR]; KR (UsOnly)
Inventors:
JUN, Hyung-Kyun; KR
CHOI, Bong-Woong; KR
LEE, Young-Ik; KR
SOHN, Mi-Jin; KR
Agent:
LEE, Duck-Rog; Sungkog Building 3rd floor 823-22, Yorksam-dong Kangnam-ku Seoul, 135-080, KR
Priority Data:
1997-2005422.05.1997KR
Title (EN) THE PRODUCTION OF HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR
(FR) PRODUCTION DE FACTEUR HUMAIN STIMULANT LES COLONIES DE GRANULOCYTES
Abstract:
(EN) The present invention relates to the production of human granulocyte colony-stimulating factor (hG-CSF). A recombinant plasmid (pYHM-G-CSF) containing cDNA for hG-CSF was produced and introduced into Escherichia coli (E. coli) which was developed to recombinant bacteria. The recombinant bacteria have high expression ability to 1.7g hG-CSF from 1L culture media. The refolded and purified hG-CSF has comparable biological activity of G-CSF.
(FR) Production de facteur humain stimulant les colonies de granulocytes (hG-CSF). Un plasmide de recombinaison (pYHM-G-CSF) contenant de l'ADNc pour hG-CSF a été produit et introduit dans Escherichia coli (E. coli) pour obtenir des bactéries de recombinaison. Lesdites bactéries présentent une forte capacité d'expression, de l'ordre de 1,7g de hG-CSF pour un litre de milieu de culture. Le hG-CSF renaturé et purifié possède une activité biologique comparable à G-CSF.
Designated States: CN, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)