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1. (WO1998053067) $i(NBC), A GENE THAT ENCODES A MEMBER OF THE BICARBONATE TRANSPORTER FAMILY OF PROTEINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/053067 International Application No.: PCT/US1998/010297
Publication Date: 26.11.1998 International Filing Date: 20.05.1998
Chapter 2 Demand Filed: 18.12.1998
IPC:
C07K 14/46 (2006.01) ,C07K 14/47 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
Applicants:
YALE UNIVERSITY [US/US]; 451 College Street New Haven, CT 06510, US (AllExceptUS)
BEVENSEE, Mark, O. [US/US]; US (UsOnly)
SCHMITT, Bernhard, M. [DE/US]; US (UsOnly)
ROMERO, Michael, F. [US/US]; US (UsOnly)
BORON, Walter, F. [US/US]; US (UsOnly)
BIEMESDERFER, Daniel [US/US]; US (UsOnly)
DAVIS, Bruce, A. [US/US]; US (UsOnly)
SUSSMAN, Caroline, R. [US/US]; US (UsOnly)
CHOI, Inyeong [KR/US]; US (UsOnly)
AALKJAER, Christian [DK/DK]; DK (UsOnly)
GRICHTCHENKO, Irina I. [RU/US]; US (UsOnly)
Inventors:
BEVENSEE, Mark, O.; US
SCHMITT, Bernhard, M.; US
ROMERO, Michael, F.; US
BORON, Walter, F.; US
BIEMESDERFER, Daniel; US
DAVIS, Bruce, A.; US
SUSSMAN, Caroline, R.; US
CHOI, Inyeong; US
AALKJAER, Christian; DK
GRICHTCHENKO, Irina I.; US
Agent:
ADLER, Reid, G. ; Morgan Lewis & Bockius 1800 M Street, N.W. Washington, DC 20036-5869, US
Priority Data:
60/047,13120.05.1997US
Title (EN) $i(NBC), A GENE THAT ENCODES A MEMBER OF THE BICARBONATE TRANSPORTER FAMILY OF PROTEINS
(FR) LE $i(NBC), GENE CODANT POUR UN MEMBRE LA FAMILLE DE PROTEINES TRANSPORTEUSES DE BICARBONATE
Abstract:
(EN) The present invention provides the nucleotide sequence of nucleic acid molecules that encode members of the Sodium Bicarbonate Cotransporter (NBC) family of proteins. Based on this disclosure, the present invention provides isolated NBC protein, isolated NBC encoding nucleic acid molecules, methods of isolating nucleic acid molecules that encode other members of the NBC family of proteins, methods for identifying agents that agonize or antagonize NBC activity, methods of using agents that agonize or antagonize NBC activity to modulate biological and pathological processes, and methods of assaying for NBC activity.
(FR) L'invention porte sur des séquences nucléotidiques de molécules d'acide nucléique codant pour des protéines membres de la famille des 'cotranporteurs du bicarbonate de soude' (NBC). Dans le cadre de cette découverte, l'invention porte également sur des protéines de NBC isolées, sur des molécules d'acide nucléique isolées codant pour le NBC, sur des procédés d'isolement des molécules d'acide nucléique codant pour d'autres protéines membres de la famille des NBC, sur des procédés d'identification d'agents agonistes ou antagonistes de l'activité des NBC modulant certains processus biologiques ou pathologiques, et sur des procédés de contrôle de l'activité des NBC.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998076892