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1. (WO1998053059) NUCLEIC ACID BINDING PROTEINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/053059 International Application No.: PCT/GB1998/001514
Publication Date: 26.11.1998 International Filing Date: 26.05.1998
Chapter 2 Demand Filed: 14.10.1998
IPC:
A61K 38/00 (2006.01) ,C07K 14/47 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
Applicants:
MEDICAL RESEARCH COUNCIL [GB/GB]; 20 Park Crescent London W1N 4AL, GB (AllExceptUS)
CHOO, Yen [GR/GB]; GB (UsOnly)
KLUG, Aaron [GB/GB]; GB (UsOnly)
ISALAN, Mark [GB/GB]; GB (UsOnly)
Inventors:
CHOO, Yen; GB
KLUG, Aaron; GB
ISALAN, Mark; GB
Agent:
MASCHIO, Antonio; D. Young & Co. 21 New Fetter Lane London EC4A 1DA, GB
Priority Data:
9710807.023.05.1997GB
Title (EN) NUCLEIC ACID BINDING PROTEINS
(FR) PROTEINES DE LIAISON D'ACIDE NUCLEIQUE
Abstract:
(EN) The invention provides a method for preparing a nucleic acid binding protein of the Cys2-His2 zinc finger class capable of binding to a target nucleic acid sequence, wherein binding to the 5' base of the triplet by an $g(a)-helical zinc finger nucleic acid binding motif in the protein is determined as follows: if the 5' base in the triplet is A, then position +6 in the $g(a)-helix is Glu, Asn or Val; if the 5' base in the triplet is C, then position +6 in the $g(a)-helix is Ser, Thr, Val, Ala, Glu or Asn.
(FR) L'invention concerne une méthode de préparation d'une protéine de liaison d'acide nucléique de la classe des doigts à zinc Cys2-His2 capable de se lier à une séquence d'acide nucléique cible, la liaison à la base 5' du triplet par un motif de liaison d'acide nucléique de doigt à zinc $g(a)-hélicoïdal dans la protéine étant déterminée comme suit: si la base 5' dans le triplet est A, alors la position +6 dans l'hélice $g(a) est Glu, Asn ou Val; si la base 5' dans le triplet est C, alors la position +6 dans l'hélice $g(a) est Ser, Thr, Val, Ala, Glu ou Asn.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998075424