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1. (WO1998052971) $i(DIROFILARIA) AND $I(BRUGIA) THIOREDOXIN PEROXIDASE TYPE-2 (TPx-2) PROTEINS, NUCLEIC ACID MOLECULES, AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052971 International Application No.: PCT/US1998/010474
Publication Date: 26.11.1998 International Filing Date: 21.05.1998
Chapter 2 Demand Filed: 17.12.1998
IPC:
A61K 38/00 (2006.01) ,C07K 16/40 (2006.01) ,C12N 9/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
08
acting on hydrogen peroxide as acceptor (1.11)
Applicants:
HESKA CORPORATION [US/US]; 1613 Prospect Parkway Fort Collins, CO 80525, US
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION [US/US]; 601 So. Howes Fort Collins, CO 80521, US
Inventors:
CHANDRASHEKAR, Ramaswamy; US
TSUJI, Naotoshi; US
Agent:
HANLEY, Elizabeth, A. ; Lahive & Cockfield, LLP 28 State Street Boston, MA 02109, US
Priority Data:
08/862,54023.05.1997US
Title (EN) $i(DIROFILARIA) AND $I(BRUGIA) THIOREDOXIN PEROXIDASE TYPE-2 (TPx-2) PROTEINS, NUCLEIC ACID MOLECULES, AND USES THEREOF
(FR) PROTEINES ET MOLECULES D'ACIDES NUCLEIQUES DE THIOREDOXINE PEROXYDASE DE TYPE 2 (TPX-2) DE $i(DIROFILARIA) ET $i(BRUGIA), ET UTILISATIONS DE CELLES-CI
Abstract:
(EN) The present invention relates to: $i(Dirofiliaria) and $i(Brugia) thioredoxin peroxidase type-2(TPx-2) proteins; $i(Dirofilaria) $i(Brugia) TPx-2 nucleic acid molecules, including those that encode such TPx-2 proteins; antibodies raised against such TPx-2 proteins; and compounds that inhibit $i(Dirofilaria) and $i(Brugia) TPx-2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
(FR) La présente invention a trait à: des protéines de thioredoxine peroxydase de type 2 (TPx-2) de $i(Dirofilaria) et $i(Brugia); des molécules d'acides nucléiques de TPx-2 de $i(Dirofilaria) et $i(Brugia), y compris celles qui codent pour les protéines de TPx-2; des anticorps agissant contre ces protéines de TPx-2; et des composés inhibant l'activité de TPx-2 de $i(Dirofilaria) et $i(Brugia). La présente invention concerne également des procédés permettant d'obtenir ces protéines, molécules d'acides nucléiques, anticorps et composés inhibiteurs. La présente invention se réfère également à des compositions thérapeutiques contenant ces protéines, molécules d'acides nucléiques, anticorps et/ou composés inhibiteurs, ainsi qu'à l'utilisation de ces compositions thérapeutiques pour prémunir des animaux contre des maladies provoquées par des helminthes parasites.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998075897