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1. (WO1998052967) NEW ECHINOCANDIDE DERIVATIVES WITH ANTIMICROBIAL ACTIVITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052967 International Application No.: PCT/JP1998/002168
Publication Date: 26.11.1998 International Filing Date: 18.05.1998
Chapter 2 Demand Filed: 24.11.1998
IPC:
A61K 38/00 (2006.01) ,C07K 7/56 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50
Cyclic peptides containing at least one abnormal peptide link
54
with at least one abnormal peptide link in the ring
56
the cyclisation not occurring through 2,4-diamino-butanoic acid
Applicants:
FUJISAWA PHARMACEUTICAL CO., LTD. [JP/JP]; 4-7, Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541-8514, JP (AllExceptUS)
HORI, Yasuhiro [JP/JP]; JP (UsOnly)
TSURUMI, Yasuhisa [JP/JP]; JP (UsOnly)
TAKASE, Shigehiro [JP/JP]; JP (UsOnly)
HATANAKA, Hiroshi [JP/JP]; JP (UsOnly)
SAKAMOTO, Kazutoshi [JP/JP]; JP (UsOnly)
HASHIMOTO, Seiji [JP/JP]; JP (UsOnly)
OHKI, Hidenori [JP/JP]; JP (UsOnly)
TOJO, Takashi [JP/JP]; JP (UsOnly)
MATSUDA, Keiji [JP/JP]; JP (UsOnly)
KAWABATA, Kohji [JP/JP]; JP (UsOnly)
Inventors:
HORI, Yasuhiro; JP
TSURUMI, Yasuhisa; JP
TAKASE, Shigehiro; JP
HATANAKA, Hiroshi; JP
SAKAMOTO, Kazutoshi; JP
HASHIMOTO, Seiji; JP
OHKI, Hidenori; JP
TOJO, Takashi; JP
MATSUDA, Keiji; JP
KAWABATA, Kohji; JP
Agent:
SEKI, Hideo; Fujisawa Pharmaceutical Co., Ltd. Osaka Factory 1-6, Kashima 2-chome Yodogawa-ku, Osaka-shi Osaka 532-8514, JP
Priority Data:
PO 691821.05.1997AU
Title (EN) NEW ECHINOCANDIDE DERIVATIVES WITH ANTIMICROBIAL ACTIVITY
(FR) NOUVEAU COMPOSE
Abstract:
(EN) The invention relates to new polypeptide compounds represented by formula (I), wherein R1 is hydrogen, etc., R2 is hydrogen, etc., R3 is hydrogen, etc., and R4 is hydrogen, etc., or a salt thereof which have antimicrobial activities (especially antifungal activities), inhibitory activity on $g(b)-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including $i(Pneumocystis carinii) infection (e.g. $i(Pneumocystis carinii pneumonia) in a human being or an animal.
(FR) L'invention concerne de nouveaux composés polypeptidiques, ou un sel de ces derniers, représentés par la formule (I), dans laquelle R1 représente hydrogène, etc., R2 représente hydrogène, etc., R3 représente hydrogène, etc., et R4 représente hydrogène, etc.. Ces nouveaux composés présentent une activité antimicrobienne (en particulier une activité antifongique) et une activité inhibitrice sur la $g(b)-1,3-glucane synthase. L'invention concerne également un procédé pour préparer ces nouveaux composés, une composition pharmaceutique les renfermant, ainsi qu'une méthode pour le traitement prophylactique et/ou thérapeutique de maladies infectieuses, telle qu'une infection à $i(Pneumocystis carinii) (par ex. la pneumonie interstitielle à $i(Pneumocystis carinii), chez un être humain ou un animal.
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Designated States: BR, CA, CN, JP, KR, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0983297US6331521JP2002502239