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1. (WO1998052944) HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052944 International Application No.: PCT/US1998/010174
Publication Date: 26.11.1998 International Filing Date: 18.05.1998
Chapter 2 Demand Filed: 09.12.1998
IPC:
C07D 261/18 (2006.01) ,C07D 277/32 (2006.01) ,C07D 401/12 (2006.01) ,C07D 413/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
261
Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
02
not condensed with other rings
06
having two or more double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18
Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
SUGEN, INC. [US/US]; 351 Galveston Drive Redwood City, CA 94063, US
Inventors:
McMAHON, Gerald; US
TANG, Peng, Cho; US
SHAWVER, Laura, Kay; US
HIRTH, Klaus, Peter; US
Agent:
ROSE, Bernard, F. ; Lyon & Lyon LLP Suite 4700 633 West Fifth Street Los Angeles, CA 90071-2066, US
Priority Data:
60/046,94519.05.1997US
60/047,08419.05.1997US
60/056,62320.08.1997US
60/061,59010.10.1997US
Title (EN) HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS
(FR) COMPOSES D'HETEROARYLCARBOXAMIDE ACTIFS CONTRE LES ETATS PATHOLOGIQUES LIES AUX PROTEINE TYROSINE KINASES
Abstract:
(EN) The present invention relates to novel heteroarylcarboxamides which modulate the activity of protein tyrosine kinases and are expected to be useful in the treatment of abnormal protein tyrosine kinase activity driven disorders, to methods for the treatment of inappropriate FGFR activity related disorders with the heteroarylcarboxamide, N-(4-trifluoromethyl-phenyl)-5-methylisoxazole-4-carboxamide, and to the treatment of solid tumor cancers, especially glioblastoma and astrocytoma, with a combination of a nitrosourea, preferably BCNU (carmustin) and N-(4-trifluoromethyl-phenyl)-5-methylisoxazole-4-carboxamide.
(FR) Nouveaux hétéroarylcarboxamides qui modulent l'activité des protéine tyrosine kinases et dont on pense qu'ils sont utiles dans le traitement d'états pathologiques dus à l'activité anormale des protéine tyrosine kinases, méthodes de traitement d'états pathologiques liés l'activité inappropriée des récepteurs de facteur croissance des fibroblastes (FGFR) à l'aide de l'hétéroarylcarboxamide N-(4-trifluorométhyl-phényl)-5-méthylisoxazole-4-carboxamide et traitement de cancers à tumeurs solides, en particulier le glioblastome et l'astrocytome, avec une combinaison de nitrosourée, de préférence BCNU (carmustine), et de N-(4-trifluorométhyl-phényl)-5-méthylisoxazole-4-carboxamide.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1012150CA2302438AU1998076879