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1. (WO1998052940) SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052940 International Application No.: PCT/US1998/010436
Publication Date: 26.11.1998 International Filing Date: 22.05.1998
Chapter 2 Demand Filed: 16.12.1998
IPC:
C07D 401/04 (2006.01) ,C07D 401/14 (2006.01) ,C07D 403/04 (2006.01) ,C07D 405/14 (2006.01) ,C07D 409/14 (2006.01) ,C07D 413/14 (2006.01) ,C07D 417/14 (2006.01) ,C07D 453/02 (2006.01) ,C07D 471/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02
containing not further condensed quinuclidine ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
G.D. SEARLE AND CO. [US/US]; P.O. Box 5110 Chicago, IL 60680, US (AllExceptUS)
ANANTANARAYAN, Ashok [US/US]; US (UsOnly)
CLARE, Michael [GB/US]; US (UsOnly)
COLLINS, Paul, W. [US/US]; US (UsOnly)
CRICH, Joyce, Zuowu [CN/US]; US (UsOnly)
DEVRAJ, Rajesh [IN/US]; US (UsOnly)
FLYNN, Daniel, L. [US/US]; US (UsOnly)
GENG, Lifeng [CN/US]; US (UsOnly)
HANSON, Gunnar, J. [US/US]; US (UsOnly)
KOSZYK, Francis, J. [US/US]; US (UsOnly)
LIAO, Shuyuan [CN/US]; US (UsOnly)
PARTIS, Richard, A. [US/US]; US (UsOnly)
RAO, Shashidhar, N. [IN/US]; US (UsOnly)
SELNESS, Shaun, Raj [US/US]; US (UsOnly)
SOUTH, Michael, S. [US/US]; US (UsOnly)
STEALEY, Michael, A. [US/US]; US (UsOnly)
WEIER, Richard, M. [US/US]; US (UsOnly)
XU, Xiangdong [CN/US]; US (UsOnly)
KHANNA, Ish K. [IN/US]; US (UsOnly)
YU, Ki; US (UsOnly)
Inventors:
ANANTANARAYAN, Ashok; US
CLARE, Michael; US
COLLINS, Paul, W.; US
CRICH, Joyce, Zuowu; US
DEVRAJ, Rajesh; US
FLYNN, Daniel, L.; US
GENG, Lifeng; US
HANSON, Gunnar, J.; US
KOSZYK, Francis, J.; US
LIAO, Shuyuan; US
PARTIS, Richard, A.; US
RAO, Shashidhar, N.; US
SELNESS, Shaun, Raj; US
SOUTH, Michael, S.; US
STEALEY, Michael, A.; US
WEIER, Richard, M.; US
XU, Xiangdong; US
KHANNA, Ish K.; US
YU, Ki; US
Agent:
ROEDEL, John, K., Jr. ; Senniger, Powers, Leavitt and Roedel 16th floor One Metropolitan Square St. Louis, MO 63102, US
BEIL, Hans Chr.; Adelonstrasse 58 Postfach 80 01 40 D-65901 Frankfurt AM Main, DE
Priority Data:
60/047,57022.05.1997US
Title (EN) SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS
(FR) PYRAZOLES SUBSTITUES UTILISES COMME INHIBITEURS DE p38 KINASE
Abstract:
(EN) A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (I) wherein R1, R2, R3 and R4 are as described in the specification.
(FR) L'invention concerne une classe de dérivés de pyrazoles, utile pour traiter des troubles associés à la p38 kinase. Des composés particulièrement intéressants sont définis par la formule (I), dans laquelle R1, R2, R3 et R4 sont tels que décrits dans la description.
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Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1999-4118IS5257NO19995695SK157899TR2000/00235YUP-600/99
MXPA/a/1999/010759APAP 1246KR1020010012827KR1020010012854SG68964VN4796
IL132991BRPI9809147EP1000055JP2002508754 CN1264377CA2291115
EA199900953NZ501112AU1998075883GEP20033053B