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1. (WO1998052920) CHEMICAL PROCESS FOR THE REDUCTION OF 1-SUBSTITUTED -3-HYDROXYMETHYL-4- (4-FLUOROPHENYL)TETRAHYDROPYRIDINES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052920 International Application No.: PCT/EP1998/002826
Publication Date: 26.11.1998 International Filing Date: 13.05.1998
Chapter 2 Demand Filed: 06.11.1998
IPC:
C07D 211/22 (2006.01) ,C07D 405/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
08
with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18
with substituted hydrocarbon radicals attached to ring carbon atoms
20
with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
22
by oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
KNOLL AKTIENGESELLSCHAFT [DE/DE]; Knollstrasse D-67061 Ludwigshafen, DE (AllExceptUS)
BRENNAN, James, Patrick [GB/GB]; GB (UsOnly)
Inventors:
BRENNAN, James, Patrick; GB
Agent:
MILLER, Thomas, Kerr ; BASF Aktiengesellschaft D-67056 Ludwigshafen, DE
Priority Data:
9710004.417.05.1997GB
Title (EN) CHEMICAL PROCESS FOR THE REDUCTION OF 1-SUBSTITUTED -3-HYDROXYMETHYL-4- (4-FLUOROPHENYL)TETRAHYDROPYRIDINES
(FR) PROCEDE CHIMIQUE POUR LA REDUCTION DE SUBSTITUES EN 3-HYDROXYMETHYL-4- (-4-FLUOROPHENYL)TETRAHYDROPYRIDINES
Abstract:
(EN) A process for the preparation of a compound of formula (I), in which R1 represents an amine protecting group wherein a compound of formula (II), in which R1 is as defined above, is reduced by a metal hydride in the presence of an inorganic salt in the presence of a diluent.
(FR) L'invention concerne un procédé pour la préparation d'un composé représenté par la formule (I) où R1 est un groupe amino de protection, dans lequel un composé représenté par la formule (II) où R1 a la même signification, est réduit par un hydrure métallique en présence d'un sel inorganique en présence d'un diluant.
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Designated States: AL, AU, BG, BR, BY, CA, CN, CZ, GE, HU, ID, IL, JP, KR, KZ, LT, LV, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TR, UA, US
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1999-4081NO19995619SK149599TR1999/02823MXPA/a/1999/009667KR1020010012620
SG68400IL132360ES2171299EP0983237RU02205178US6326496
JP2001525838 CN1255916CA2289013NZ501692DK0983237AU1998079121