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1. (WO1998052894) CYCLOHEXANEDIOL DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/052894 International Application No.: PCT/EP1998/002762
Publication Date: 26.11.1998 International Filing Date: 12.05.1998
Chapter 2 Demand Filed: 08.12.1998
IPC:
C07C 35/17 (2006.01) ,C07F 7/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
35
Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
02
monocyclic
08
containing six-membered rings
17
with unsaturation only outside the ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7
Compounds containing elements of the 4th Group of the Periodic System
02
Silicon compounds
08
Compounds having one or more C-Si linkages
18
Compounds having one or more C-Si linkages as well as one or more C-O-Si linkages
Applicants:
F.HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH
Inventors:
BAUER, Franz; CH
COURTNEY, Lawrence, F.; US
Agent:
KJELLSAA-BERGER, Hanny; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data:
97108355.523.05.1997EP
Title (EN) CYCLOHEXANEDIOL DERIVATIVES
(FR) DERIVES CYCLOHEXANEDIOL
Abstract:
(EN) The compound, (E)-(1R,3R)-5-[(R)-11-hydroxy-7,11-dimethyl-dodec-2-enylidene]-cyclohexane-1,3-diol of formula (I) is useful in the treatment or prevention of hyperproliferative skin diseases, particularly psoriasis, basal cell carcinomas, disorders of keratinization and keratosis; or for reversing the conditions associated with photodamage.
(FR) L'invention concerne le composé (E)-(1R, 3R)-5-[(R)-11-hydroxy-7,11-diméthyl-dodec-2-énylidène]-cyclohexane-1,3-diol représenté par la formule I et convenant particulièrement au traitement ou à la prévention de maladies hyperprolifératives de la peau, particulièrement le psoriasis, le carcinome basocellulaire, les troubles de la kératinisation ou la kératose ou pour inverser le cours de maladies liées aux effets nocifs du soleil.
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Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)