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1. (WO1998052607) 88KDA TUMORIGENIC GROWTH FACTOR AND ANTAGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052607 International Application No.: PCT/US1998/010555
Publication Date: 26.11.1998 International Filing Date: 22.05.1998
Chapter 2 Demand Filed: 03.12.1998
IPC:
A61K 38/00 (2006.01) ,C07K 14/475 (2006.01) ,C07K 16/22 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
22
against growth factors
Applicants:
SERRERO, Ginette [FR/US]; US
Inventors:
SERRERO, Ginette; US
Agent:
BRADY, James, W., Jr.; Dickstein Shapiro Morin & Oshinsky LLP 2101 L Street, N.W. Washington, DC 20037, US
Priority Data:
08/863,07923.05.1997US
08/991,86216.12.1997US
Title (EN) 88KDA TUMORIGENIC GROWTH FACTOR AND ANTAGONISTS
(FR) FACTEUR DE CROISSANCE TUMORIGENE ET ANTAGONISTES DE 88KDA
Abstract:
(EN) This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expression or action. Antagonists to an 88KDa autocrine growth and tumorigenicity stimulator are provided which inhibit its expression or biological activity. The antagonists include antisense oligonucleotides and antibodies.
(FR) L'invention concerne des produits et des méthodes permettant de traiter le cancer et de diagnostiquer l'action tumorigène et d'autres maladies associées à une altération dans l'expression ou l'action de GP88. L'invention concerne également des antagonistes d'un activateur de la croissance autocrine et l'action tumérogène de 88 Kda, lesdits antagonistes inhibant son expression ou son activité biologique. Ces antagonistes comprennent notamment des oligonucléotides et des anticorps antisens.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1011723EP1356824CA2290602AU1998077978DK1011723