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1. (WO1998052603) AN INFLUENZA ENVELOPED DNA VACCINE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/052603 International Application No.: PCT/EP1998/003050
Publication Date: 26.11.1998 International Filing Date: 22.05.1998
Chapter 2 Demand Filed: 21.12.1998
IPC:
A61K 9/00 (2006.01) ,A61K 9/127 (2006.01) ,A61K 39/145 (2006.01) ,A61K 39/165 (2006.01) ,A61K 48/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
145
Orthomyxoviridae, e.g. influenza virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
155
Paramyxoviridae, e.g. parainfluenza virus
165
Mumps or measles virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
CUSI, Maria, Grazia [IT/IT]; IT (UsOnly)
GLÜCK, Reinhard [CH/CH]; CH (UsOnly)
WÄLTI, Ernst [CH/CH]; CH (UsOnly)
SCHWEIZ. SERUM- & IMPFINSTITUT BERN [CH/CH]; Postfach 2707 CH-3001 Bern, CH (AllExceptUS)
Inventors:
CUSI, Maria, Grazia; IT
GLÜCK, Reinhard; CH
WÄLTI, Ernst; CH
Agent:
VOSSIUS & PARTNER; Siebertstrasse 4 D-81675 München, DE
Priority Data:
97108390.223.05.1997EP
Title (EN) AN INFLUENZA ENVELOPED DNA VACCINE
(FR) VACCIN COMPRENANT DE L'ADN A ENVELOPPE DU VIRUS DE LA GRIPPE
Abstract:
(EN) Described are virosomes comprising cationic lipids, biologically active influenza hemagglutinin protein or biologically active derivatives thereof and nucleic acids encoding antigens from pathogenic sources in their insides, preferably antigens from mumps virus wherein said antigens are derived from conserved external and internal proteins of said virus. Provided are virosomes which may advantageously be formulated as vaccines capable of inducing strong neutralizing antibody and cytotoxic T cell responses as well as protection to pathogenic sources such as a mumps virus. Furthermore, vaccines comprising recombinant DNA derived from DNA encoding conserved external and internal proteins from mumps virus are described.
(FR) L'invention concerne des virosomes comprenant des lipides cationiques, de la protéine d'hémagglutinine de la grippe biologiquement active, ou des dérivés biologiquement actifs de ces derniers, et des acides nucléiques codant des antigènes à partir de sources pathogènes dans leurs intérieurs, de préférence, des antigènes provenant du virus des oreillons. Ces antigènes sont dérivés de protéines externes et internes conservées de ce virus. L'invention traite aussi de virosomes qui peuvent être formulés, de manière avantageuse, comme vaccins permettant d'induire des réponses des lymphocytes T cytotoxiques et des anticorps à forte neutralisation, ainsi qu'une protection contre les sources pathogènes comme le virus des oreillons. En outre, l'invention a pour objet des vaccins comprenant de l'ADN de recombinaison dérivés de l'ADN codant des protéines internes et externes conservées, provenant du virus des oreillons.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)