Search International and National Patent Collections

1. (WO1998052602) USE OF HYALURONIDASE IN THE MANUFACTURE OF AN OPHTHALMIC PREPARATION FOR LIQUEFYING VITREOUS HUMOR IN THE TREATMENT OF EYE DISORDERS

Pub. No.:    WO/1998/052602    International Application No.:    PCT/US1998/010578
Publication Date: Fri Nov 27 00:59:59 CET 1998 International Filing Date: Sat May 23 01:59:59 CEST 1998
IPC: A61K 38/47
Applicants: ADVANCED CORNEAL SYSTEMS, INC.
KARAGEOZIAN, Hampar, L.
KARAGEOZIAN, Vicken, H.
KENNEY, Maria, Cristina
FLORES, Jose Luis Gutierrez
ARAGON, Gabriel Arturo Carpio
NESBURN, Anthony, B.
Inventors: KARAGEOZIAN, Hampar, L.
KARAGEOZIAN, Vicken, H.
KENNEY, Maria, Cristina
FLORES, Jose Luis Gutierrez
ARAGON, Gabriel Arturo Carpio
NESBURN, Anthony, B.
Title: USE OF HYALURONIDASE IN THE MANUFACTURE OF AN OPHTHALMIC PREPARATION FOR LIQUEFYING VITREOUS HUMOR IN THE TREATMENT OF EYE DISORDERS
Abstract:
An enzymatic method is provided for treating ophthalmic disorders of the mammalian eye. Prevention of neovascularization and the increased rate of clearance from the vitreous of materials toxic to retina is accomplished by administering an amount of hyaluronidase effective to liquefy the vitreous humor of the treated eye without causing toxic damage to the eye. Liquefaction of the vitreous humor increases the rate of liquid exchange from the vitreal chamber. This increase in exchange removes those materials and conditions whose presence causes ophthalmological and retinal damage.