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1. (WO1998052602) USE OF HYALURONIDASE IN THE MANUFACTURE OF AN OPHTHALMIC PREPARATION FOR LIQUEFYING VITREOUS HUMOR IN THE TREATMENT OF EYE DISORDERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052602 International Application No.: PCT/US1998/010578
Publication Date: 26.11.1998 International Filing Date: 22.05.1998
Chapter 2 Demand Filed: 09.12.1998
IPC:
A61K 38/47 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
47
acting on glycosyl compounds (3.2), e.g. cellulases, lactases
Applicants:
ADVANCED CORNEAL SYSTEMS, INC. [US/US]; Suite 100 15279 Alton Parkway Irvine, CA 92618, US (AllExceptUS)
KARAGEOZIAN, Hampar, L. [US/US]; US (UsOnly)
KARAGEOZIAN, Vicken, H. [US/US]; US (UsOnly)
KENNEY, Maria, Cristina [US/US]; US (UsOnly)
FLORES, Jose Luis Gutierrez [MX/MX]; MX (UsOnly)
ARAGON, Gabriel Arturo Carpio [MX/MX]; MX (UsOnly)
NESBURN, Anthony, B. [US/US]; US (UsOnly)
Inventors:
KARAGEOZIAN, Hampar, L.; US
KARAGEOZIAN, Vicken, H.; US
KENNEY, Maria, Cristina; US
FLORES, Jose Luis Gutierrez; MX
ARAGON, Gabriel Arturo Carpio; MX
NESBURN, Anthony, B.; US
Agent:
ALTMAN, Daniel, E.; Knobbe, Martens, Olson & Bear 16th floor 620 Newport Center Drive Newport Beach, CA 92660, US
Priority Data:
08/862,62022.05.1997US
Title (EN) USE OF HYALURONIDASE IN THE MANUFACTURE OF AN OPHTHALMIC PREPARATION FOR LIQUEFYING VITREOUS HUMOR IN THE TREATMENT OF EYE DISORDERS
(FR) UTILISATION DE L'HYALURONIDASE DANS LA FABRICATION D'UNE PREPARATION OPHTALMIQUE DESTINEE A FLUIDIFIER L'HUMEUR VITREUSE DANS LE TRAITEMENT DE CERTAINS TROUBLES OCULAIRES
Abstract:
(EN) An enzymatic method is provided for treating ophthalmic disorders of the mammalian eye. Prevention of neovascularization and the increased rate of clearance from the vitreous of materials toxic to retina is accomplished by administering an amount of hyaluronidase effective to liquefy the vitreous humor of the treated eye without causing toxic damage to the eye. Liquefaction of the vitreous humor increases the rate of liquid exchange from the vitreal chamber. This increase in exchange removes those materials and conditions whose presence causes ophthalmological and retinal damage.
(FR) Cette invention concerne un procédé enzymatique qui permet de traiter des troubles ophtalmiques de l'oeil d'un mammifère. Pour prévenir la néovascularisation et augmenter la vitesse d'élimination de matières toxiques pour la rétine présentes dans le corps vitré, on administre une quantité efficace d'hyaluronidase pour fluidifier l'humeur vitreuse de l'oeil traité sans provoquer de dommage toxique chez ce dernier. La fluidification de l'humeur vitreuse augmente la vitesse de l'échange de liquide dans l'espace compris entre la rétine et la face postérieure du cristallin. Cet accroissement de l'échange permet d'éliminer les matières et les conditions dont la présence provoque des dommages ophtalmiques et rétiniens.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXPA/a/1999/010495KR1020010012787BRPI9809558EP0983084US20020164316US20030170224
US20050069531JP2002503229 CN1257430CA2288622AU1998076936DK0983084
AU2001093449