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1. (WO1998052594) COMPOSITIONS FOR ENHANCING IMMUNOSUPPRESSANTS' PHARMACEUTICAL ACTIVITIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/052594    International Application No.:    PCT/FI1998/000418
Publication Date: 26.11.1998 International Filing Date: 18.05.1998
Chapter 2 Demand Filed:    16.11.1998    
IPC:
A61K 38/13 (2006.01), A61K 38/21 (2006.01)
Applicants: ZAVIALOV, Vladimir Petrovich [RU/RU]; (RU).
VASILENKO, Raisa Nikolaevna [RU/RU]; (RU).
DOLGIKH, Dmitry Aleksandrovich [RU/RU]; (RU).
KIRPICHNIKOV, Mikhail Petrovich [RU/RU]; (RU).
NAVOLOTSKAYA, Elena Vitalievna [RU/RU]; (RU).
KORPELA, Timo, Kalevi [FI/FI]; (FI)
Inventors: ZAVIALOV, Vladimir Petrovich; (RU).
VASILENKO, Raisa Nikolaevna; (RU).
DOLGIKH, Dmitry Aleksandrovich; (RU).
KIRPICHNIKOV, Mikhail Petrovich; (RU).
NAVOLOTSKAYA, Elena Vitalievna; (RU).
KORPELA, Timo, Kalevi; (FI)
Agent: KORPELA, Timo, Kalevi; Kasarminkatu 5 as. 8, FIN-20500 Turku (FI)
Common
Representative:
KORPELA, Timo, Kalevi; Kasarminkatu 5 as. 8, FIN-20500 Turku (FI)
Priority Data:
972121 19.05.1997 FI
Title (EN) COMPOSITIONS FOR ENHANCING IMMUNOSUPPRESSANTS' PHARMACEUTICAL ACTIVITIES
(FR) COMPOSITIONS STIMULANT L'ACTIVITE PHARMACEUTIQUE DES IMMUNOSUPPRESSEURS
Abstract: front page image
(EN)The present invention provides the compositions for efficient amplification of immunosuppressive activity of cyclosporins, FK506 or rapamycin to decrease therapeutical dose of immunosuppressants, and as the consequence to avoid their undesirable side effects during organ and tissue transplantation, and treatment of different diseases. These compositions include cyclosporins, FK506 or rapamycin and biologically active peptides corresponding to the high-affinity binding/anti-lymphoproliferative site of IFNs-a,b,w,t, or recombinant proteins having the amino acid sequences corresponding to the said site.
(FR)L'invention concerne des compositions permettant d'amplifier de manière efficace l'activité immunosuppressive des ciclosporines, telles que la FK506 ou la rapamycine, de façon à diminuer leur dose thérapeutique, ce qui élimine leurs effets secondaires indésirables durant les transplantations d'organes ou de tissus et le traitement de différentes maladies. Ces compositions contiennent des ciclosporines, la FK506 ou la rapamycine, ainsi que des peptides biologiquement actifs correspondant au site de liaison à haute affinité et/ou anti-lymphoprolifératif des IFN a, b, w, t, ou bien des protéines recombinantes qui renferment des séquences d'acides aminés correspondant audit site.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)