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1. (WO1998052582) NON-MYELOABLATIVE TOLEROGENIC TREATMENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052582 International Application No.: PCT/US1998/010575
Publication Date: 26.11.1998 International Filing Date: 22.05.1998
Chapter 2 Demand Filed: 22.12.1998
IPC:
A01K 67/027 (2006.01) ,A61K 35/12 (2006.01) ,A61K 35/28 (2006.01) ,A61K 39/00 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. [IL/IL]; Kiryat Hadassah P.O. Box 12000 91120 Jerusalem, IL (AllExceptUS)
BAXTER INTERNATIONAL INC. [US/US]; One Baxter Parkway Deerfield, IL 60015, US (AllExceptUS)
SLAVIN, Shimon [IL/IL]; IL (UsOnly)
PRIGOZHINA, Tatyana [IL/IL]; IL (UsOnly)
Inventors:
SLAVIN, Shimon; IL
PRIGOZHINA, Tatyana; IL
Agent:
ELLINGER, Mark, S. ; Fish & Richardson P.C., P.A. Suite 3300 60 South Sixth Street Minneapolis, MN 55402, US
Priority Data:
08/862,55023.05.1997US
Title (EN) NON-MYELOABLATIVE TOLEROGENIC TREATMENT
(FR) TRAITEMENT TOLEROGENIQUE NON MYELOABLATIF
Abstract:
(EN) The present invention features a method of inducing donor-specific tolerance in a host. Tolerogenic treatments of the present invention may be administered to a host prior to transplantation of donor-derived materials. The tolerogenic treatment involves (1) administering an immunosuppressive agent to a host mammal in a non-myeloablative regimen sufficient to decrease, but not necessarily to eliminate, the host mammal's functional T lymphocyte population; (2) infusing donor antigens from a non-syngeneic donor into the host mammal; (3) eliminating those host T lymphocytes responding to the infused donor antigens using a non-myeloablative dose of lymphocytotoxic or tolerizing agent; and (4) administering donor hematopoietic cells to the host mammal.
(FR) Cette invention concerne un procédé permettant d'induire une tolérance spécifique à un donneur chez un hôte. Les traitements tolérogéniques de cette invention peuvent être administrés à un hôte avant la transplantation de matériaux provenant d'un donneur. Le traitement tolérogénique consiste (1) à administrer à un mammifère hôte une dose non myéloablative d'un agent immunosuppresseur, ladite dose étant suffisante pour réduire, sans nécessairement éliminer, la population de lymphocytes T fonctionnels du mammifère hôte; (2) à transférer chez le mammifère hôte des antigènes de donneurs provenant d'un donneur non syngénique; (3) à éliminer les lymphocytes T de l'hôte sensibles aux antigènes de donneurs perfusés à l'aide d'une dose non myéloablative d'agents lymphocytotoxiques ou d'agents induisant la tolérance; et (4) à administrer au mammifère hôte des cellules hématopoïétiques de donneurs.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXPA/a/1999/010587IL132845EP0983074JP2002502377 CA2290367AU1998077981