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1. (WO1998052580) TREATING ASTHMA BY PREVENTING AND/OR ACCOMMODATING FOR S-NITROSOTHIOL BREAKDOWN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052580 International Application No.: PCT/US1998/008978
Publication Date: 26.11.1998 International Filing Date: 07.05.1998
Chapter 2 Demand Filed: 02.12.1998
IPC:
A61K 31/00 (2006.01) ,A61K 31/195 (2006.01) ,A61K 31/42 (2006.01) ,A61K 45/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42
Oxazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants:
DUKE UNIVERSITY [US/US]; Office of Science and Technology P.O. Box 90083 Durham, NC 27708-0083, US (AllExceptUS)
THE MEDICAL COLLEGE OF WISCONSIN RESEARCH FOUNDATION, INC. [US/US]; 8701 Watertown Plank Road Milwaukee, WI 53226, US (AllExceptUS)
UNIVERSITY OF VIRGINIA PATENT FOUNDATION [US/US]; Suite 1-110, 1224 West Main Street Charlottesville, VA 22903, US (AllExceptUS)
GASTON, Benjamin [US/US]; US (UsOnly)
STAMLER, Jonathan, S. [US/US]; US (UsOnly)
GRIFFITH, Owen, W. [US/US]; US (UsOnly)
Inventors:
GASTON, Benjamin; US
STAMLER, Jonathan, S.; US
GRIFFITH, Owen, W.; US
Agent:
SPECTOR, Eric, S.; Jones, Tullar & Cooper, P.C. P.O. Box 2266 Eads Station Arlington, VA 22202, US
Priority Data:
60/047,33621.05.1997US
60/081,74015.04.1998US
Title (EN) TREATING ASTHMA BY PREVENTING AND/OR ACCOMMODATING FOR S-NITROSOTHIOL BREAKDOWN
(FR) TRAITEMENT DE L'ASTHME CONSISTANT A EMPECHER OU A INHIBER LA DECOMPOSITION DE S-NITROSOTHIOL
Abstract:
(EN) Asthma is ameliorated and mild or moderate asthma is prevented from progressing to more severe asthma by administering agents which prevent and/or accommodate for S-nitrosothiol breakdown. The method reduces requirements for systemic corticosteroids for the treatment of severe asthma.
(FR) On améliore l'asthme et on empêche l'évolution de l'asthme sans gravité et modéré vers un asthme plus grave au moyen de l'administration d'agents empêchant ou inhibant la décomposition de S-nitrosothiol. Ce procédé permet de limiter le recours à des corticostéroïdes systémiques servant à traiter les formes graves de l'asthme.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US6617355AU1998072801