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1. (WO1998052579) OPHTHALMIC COMPOSITIONS CONTAINING A DIVALENT SALT AND A NON STEROIDAL ANTI-INFLAMMATORY DRUGS AS A PRECIPITATE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052579 International Application No.: PCT/US1998/010506
Publication Date: 26.11.1998 International Filing Date: 22.05.1998
Chapter 2 Demand Filed: 21.12.1998
IPC:
A61K 9/00 (2006.01) ,A61K 33/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
06
Aluminium, calcium or magnesium; Compounds thereof
Applicants:
INSITE VISION INCORPORATED [US/US]; 965 Atlantic Avenue Alameda, CA 94501, US
Inventors:
BOWMAN, Lyle, M.; US
PFEIFFER, James, F.; US
MEMARZADEH, Eric, B.; US
ROY, Samir; US
Agent:
FREED, Joel, M. ; Howrey & Simon 1299 Pennsylvania Avenue, N.W. Box 34 Washington, DC 20004-2402, US
Priority Data:
08/863,01523.05.1997US
09/074,41908.05.1998US
Title (EN) OPHTHALMIC COMPOSITIONS CONTAINING A DIVALENT SALT AND A NON STEROIDAL ANTI-INFLAMMATORY DRUGS AS A PRECIPITATE
(FR) COMPOSITIONS OHPTALMIQUES CONTENANT UN SEL BIVALENT ET UN MEDICAMENT ANTI-INFLAMMATOIRE NON STEROIDIQUE SOUS FORME DE PRECIPITE
Abstract:
(EN) An ophthalmic composition containing a divalent salt and a non-steroidal anti-inflammatory agent as a precipitate. The composition reduces or eliminates the risk of stinging and burning the eye from topical application. Additionally a preservative system comprising a perborate salt, a polyphosphonic acid peroxy stabilizer and EDTA provides stable preservation of a variety of aqueous ophthalmic compositions.
(FR) L'invention concerne une composition ophtalmique renfermant un sel bivalent et un agent anti-inflammatoire non stéroïdique sous forme de précipité. Ladite composition réduit ou élimine les risques de brûlure ou de démangeaison de l'oeil inhérents à l'application topique. Un système de conservation comprenant un sel de perborate, un stabilisant peroxy d'acide polyphosphonique et de l'EDTA, permet en outre une conservation stable de diverses compositions ophtalmiques aqueuses.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO19995712EP0983073JP2001527574 CA2290546NZ501220AU1998075914