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1. (WO1998052567) METHOD FOR TREATING HEADACHE PAIN WITH TOPICAL LOCAL ANESTHETIC COMPOSITIONS

Pub. No.:    WO/1998/052567    International Application No.:    PCT/US1997/008378
Publication Date: Fri Nov 27 00:59:59 CET 1998 International Filing Date: Wed May 21 01:59:59 CEST 1997
IPC: A61K 31/245
A61K 47/18
A61K 47/22
Applicants: CALDWELL, Larry, J.
GALER, Bradley, Stuart
Inventors: CALDWELL, Larry, J.
GALER, Bradley, Stuart
Title: METHOD FOR TREATING HEADACHE PAIN WITH TOPICAL LOCAL ANESTHETIC COMPOSITIONS
Abstract:
Methods are provided for the treatment of a host suffering from headache pain with topical applications of a local anesthetic. The topical local anesthetic composition comprises an effective amount of a local anesthetic in combination with eucalyptol as a penetration enhancing agent, and optionally an additional penetration enhancing agent. The topical local anesthetic composition is applied to a keratinized skin site proximal to target nerves associated with the headache pain, usually to the supraorbital or occipital regions of the head. Upon application of the topical composition, the local anesthetic rapidly penetrates the skin to block conduction in the target nerves and provide pain relief to the host.