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1. (WO1998052565) SUBSTANCE DEPENDENCE TREATMENT USING OPIATE ANTAGONISTS AND SEROTONIN COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/052565 International Application No.: PCT/US1998/010289
Publication Date: 26.11.1998 International Filing Date: 19.05.1998
Chapter 2 Demand Filed: 19.11.1998
IPC:
A61K 31/485 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
485
Morphinan derivatives, e.g. morphine, codeine
Applicants:
KRISHNAN-SARIN, Suchitra [IN/US]; US (UsOnly)
O'MALLEY, Stephanie [US/US]; US (UsOnly)
FARREN, Conor [US/US]; US (UsOnly)
YALE UNIVERSITY [US/US]; Office of Cooperative Research 155 Whitney Avenue New Haven, CT 06520-8336, US (AllExceptUS)
Inventors:
KRISHNAN-SARIN, Suchitra; US
O'MALLEY, Stephanie; US
FARREN, Conor; US
Agent:
KRINSKY, Mary, M.; 79 Trumbull Street New Haven, CT 06511-3708, US
Priority Data:
60/046,16220.05.1997US
Title (EN) SUBSTANCE DEPENDENCE TREATMENT USING OPIATE ANTAGONISTS AND SEROTONIN COMPOUNDS
(FR) TRAITEMENT DE LA DEPENDANCE A CERTAINES SUBSTANCES A L'AIDE DE COMPOSES D'ANTAGONISTES D'OPIACES ET DE SEROTONINE
Abstract:
(EN) Patients are treated for alcohol, marijuana, cocaine, opiate and polysubstance dependency by administration of combination of an effective amount of an opioid antagonist such as nalmefene, naloxone, naltrexone, or a mixture of any of these, and a serotonergic medication, such as sertraline, fluoxetine, paroxetine, fluvoxamine, or odansetron. Administration of an effective amount of an opioid antagonist alone helps to prevent relapse after detoxification is complete, and addition of the serotonergic medication increases the effectiveness, decreases the side effects of the opioid antagonist, and also helps relieve effects of withdrawal.
(FR) L'invention porte sur un traitement de la dépendance de patients vis à vis de l'alcool, de la marijuana, de la cocaïne, des opiacés, consistant à leur administrer une combinaison d'une quantité efficace d'un antagoniste des opiacés tel que la nalméfène, la naloxone, la naltréxone ou un de leurs mélanges, et une médication sérotonergique de sertraline, de fluoxétine, de paroxétine, de fluvoxamine ou d'odansétron. L'administration d'une quantité efficace d'un antagoniste des opiacés seule aide à prévenir les rechutes une fois la désintoxication achevée, tandis que l'adjonction de la médication sérotonergique accroît l'efficacité des antagonistes des opiacés, tout en en réduisant les effets secondaires et en contribuant à atténuer les effets du sevrage.
Designated States: AU, CA, JP, US
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)