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1. (WO1998052557) 2,3-DIHYDROBENZOFURAN DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052557 International Application No.: PCT/JP1998/002248
Publication Date: 26.11.1998 International Filing Date: 22.05.1998
Chapter 2 Demand Filed: 15.06.1998
IPC:
A61K 31/343 (2006.01) ,C07D 307/79 (2006.01) ,C07D 307/94 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
34
having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343
condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Benzo [b] furans; Hydrogenated benzo [b] furans
79
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
94
spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
Applicants:
CHUGAI SEIYAKU KABUSHIKI KAISHA [JP/JP]; 5-1, Ukima 5-chome Kita-ku Tokyo 115-8543, JP (AllExceptUS)
ISHIKAWA, Akira [JP/JP]; JP (UsOnly)
KATO, Yoshiaki [JP/JP]; JP (UsOnly)
TAMURA, Kunio [JP/JP]; JP (UsOnly)
TAKASHIMA, Yoshiaki [JP/JP]; JP (UsOnly)
CYNSHI, Osamu [JP/JP]; JP (UsOnly)
Inventors:
ISHIKAWA, Akira; JP
KATO, Yoshiaki; JP
TAMURA, Kunio; JP
TAKASHIMA, Yoshiaki; JP
CYNSHI, Osamu; JP
Agent:
SHAMOTO, Ichio ; Yuasa and Hara Section 206, New Ohtemachi Building 2-1, Ohtemachi 2-chome Chiyoda-ku Tokyo 100-0004, JP
Priority Data:
9/17088923.05.1997JP
Title (EN) 2,3-DIHYDROBENZOFURAN DERIVATIVES
(FR) DERIVES DE 2,3-DIHYDROBENZOFURANE
Abstract:
(EN) 2,3-Dihydrobenzofuran derivatives represented by general formula (1), optically active isomers thereof, or pharmacologically acceptable salts of these, wherein R1 represents hydrogen or acyl; R2, R3, and R4 each represents hydrogen, lower alkyl, or lower alkenyl; and R5 and R6 each represents hydrogen or optionally substituted alkyl, or R5 and R6 in combination represent cycloalkyl or a saturated heterocycle containing one or more oxygen atoms or alkyl-substituted nitrogen; provided that not both of R2 and R3 are t-butyl. The compounds are useful as remedial or preventive agents for various kidney diseases and as organ preservatives.
(FR) L'invention porte sur des dérivés de 2,3-dihydrobenzofurane représentés par la formule générale (1), sur leurs isomères optiquement actifs ou sur leurs sels pharmacologiquement acceptables, formule dans laquelle R1 représente hydrogène ou acyle; R2, R3 et R4 représentent chacun hydrogène, alkyle inférieur ou alcényle inférieur; et R5 et R6 représentent chacun hydrogène ou alkyle éventuellement substitué, ou bien R5 et R6 combinés, représentent cycloalkyle ou un hétérocycle saturé contenant un ou plusieurs atomes d'oxygène ou azote substitué par alkyle; à condition que ni R2, ni R3 représente t-butyle. Ces composés sont utiles comme agents curatifs ou préventifs dans diverses maladies de reins et comme conservateurs d'organes.
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Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
KR1020010012764EP0995437US6403639US20020156296AU1998074499