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1. (WO1998052552) PROCESS FOR THE PREPARATION OF POLYAMINES AND POLYAMINE DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052552 International Application No.: PCT/US1998/009905
Publication Date: 26.11.1998 International Filing Date: 22.05.1998
IPC:
C07C 209/48 (2006.01) ,C07C 209/62 (2006.01) ,C07C 211/14 (2006.01) ,C07C 269/06 (2006.01) ,C07C 271/20 (2006.01) ,C07C 279/24 (2006.01) ,C07C 335/08 (2006.01) ,C07C 335/26 (2006.01) ,C07C 381/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
209
Preparation of compounds containing amino groups bound to a carbon skeleton
44
by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
48
by reduction of nitriles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
209
Preparation of compounds containing amino groups bound to a carbon skeleton
62
by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
02
of an acyclic saturated carbon skeleton
14
Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
269
Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
by reactions not involving the formation of carbamate groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
Esters of carbamic acids
08
having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10
with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
20
to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
279
Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
20
containing any of the groups X being a hetero atom, Y being any atom, e.g. acylguanidines
24
Y being a hetero atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
335
Thioureas, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
04
Derivatives of thiourea
06
having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
08
of a saturated carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
335
Thioureas, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
04
Derivatives of thiourea
24
containing any of the groups X being a hetero atom, Y being any atom
26
Y being a hydrogen or a carbon atom, e.g. benzoylthioureas
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
381
Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/-C07C337/142
06
Compounds containing sulfur atoms only bound to two nitrogen atoms
Applicants:
CHEM-MASTER INTERNATIONAL, INC. [US/US]; P.O. Box 563 East Setauket, NY 11733, US (AllExceptUS)
JOHNSON, Francis [US/US]; US (UsOnly)
GUPTA, Ramesh, C. [US/US]; US (UsOnly)
Inventors:
JOHNSON, Francis; US
GUPTA, Ramesh, C.; US
Agent:
MURRAY, Robert, B.; Nikaido, Marmelstein, Murray & Oram LLP Metropolitan Square Suite 330 655 15th Street, N.W. Washington, DC 20005-5701, US
Priority Data:
60/047,52823.05.1997US
Title (EN) PROCESS FOR THE PREPARATION OF POLYAMINES AND POLYAMINE DERIVATIVES
(FR) PROCEDE PERMETTANT DE PREPARER DES POLYAMINES ET DES DERIVES DE POLYAMINES
Abstract:
(EN) Disclosed are processes for the preparation of compounds of the formula (I): H2N-(CH2)n-A-(CH2)m-NH2, or (II): H2N-(CH2)n-NH-C(=NR1)-NH-(CH2)m-NH2, wherein n and m are each independently an integer from 2 to 8; A is selected from the group consisting of -NR1-, -NR1-(CH2)r-NR1- and -NR1-(CH2)r-NR1-(CH2)z-NR1-, wherein r and z are an integer ranging from 2 to 8; and R1 is hydrogen or a protecting group having a carbonyl group. Also disclosed are compounds of formula (II), pharmaceutical compositions containing them, and uses of the compounds for treating cancers susceptible to treatment with spermine, spermidine or other polyamines.
(FR) L'invention se rapporte à des procédés de préparation de composés de la formule (I): H2N-(CH2)n-A-(CH2)m-NH2 ou (II): H2N-(CH2)n-NH-C(=NR1)-NH-(CH2)m-NH2 dans lesquelles n et m représentent indépendamment un entier situé entre 2 et 8; A est sélectionné dans le groupe contenant -NR1-, -NR1-(CH2)r-NR1- et -NR1-(CH2)r-NR1-(CH2)z-NR1-, où r et z représentent des entiers situés entre 2 et 8; et R1 représente de l'hydrogène ou un groupe protecteur possédant un groupe carbonyle. L'invention concerne également des composés de la formule (II), des compositions pharmaceutiques contenant ces composés et des utilisations de ces composés dans le traitement de cancers susceptibles d'être traités avec de la spermine, de la spermidine ou d'autres polyamines.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0957905AU1998080529