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1. (WO1998052539) PROCESS FOR MAKING FLURBIPROFEN LOZENGES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052539 International Application No.: PCT/EP1998/003167
Publication Date: 26.11.1998 International Filing Date: 20.05.1998
Chapter 2 Demand Filed: 10.12.1998
IPC:
A61K 9/00 (2006.01) ,A61K 31/192 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
Applicants:
THE BOOTS COMPANY PLC [GB/GB]; 1 Thane Road West Nottingham NG2 3AA, GB (AllExceptUS)
DAY, Andrew [GB/GB]; GB (UsOnly)
JONES, Huw, Lyn [GB/GB]; GB (UsOnly)
SMITH, Carl, Simon [GB/GB]; GB (UsOnly)
Inventors:
DAY, Andrew; GB
JONES, Huw, Lyn; GB
SMITH, Carl, Simon; GB
Agent:
THACKER, Michael, Anthony; The Boots Company plc Group Patents Dept. D31, 1 Thane Road West Nottingham NG2 3AA, GB
Priority Data:
9710521.722.05.1997GB
Title (EN) PROCESS FOR MAKING FLURBIPROFEN LOZENGES
(FR) PROCEDE DE PRODUCTION DE PASTILLES DE FLURBIPROFENE
Abstract:
(EN) A process producing a pharmaceutical lozenge formulation comprising the steps of: 1) granulating a mixture of flurbiprofen and a bulking agent with a solution of a binding agent in a polar solvent to form granules; 2) melting a lozenge-forming composition; 3) mixing the granules with the molten lozenge-forming composition; 4) forming the resulting mixture into lozenges each containing a therapeutically effective amount of flurbiprofen.
(FR) L'invention concerne un procédé de production d'une formulation de pastilles de flurbiprofène, le procédé consistant: 1- à transformer en granules un mélange de flurbiprofène et de diluant avec une solution d'agent de liaison dans un solvant polaire pour former des granulés; 2- à fondre une composition de formation de pastilles; 3- à mélanger les granulés avec la composition de formation de pastilles fondue; 4- à former le mélange obtenu en pastilles contenant chacune une dose de flurbiprofène efficace sur le plan thérapeutique.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1999-4120NO19995681SK158899TR1999/02725MXPA/a/1999/010548KR1020010012739
SG68746IL132999ES2202871EP0983059RU02203046US6194003
JP2001527567 CN1255848CA2290830NZ500664AU1998079165DK0983059