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1. (WO1998052064) METHOD AND APPARATUS FOR TARGETED DRUG DELIVERY INTO A LIVING PATIENT USING MAGNETIC RESONANCE IMAGING
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/052064 International Application No.: PCT/US1998/009942
Publication Date: 19.11.1998 International Filing Date: 15.05.1998
Chapter 2 Demand Filed: 10.12.1998
IPC:
A61M 25/00 (2006.01) ,A61M 31/00 (2006.01) ,G01R 33/28 (2006.01) ,G01R 33/563 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
25
Catheters; Hollow probes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
31
Devices for introducing or retaining media, e.g. remedies, in cavities of the body
G PHYSICS
01
MEASURING; TESTING
R
MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33
Arrangements or instruments for measuring magnetic variables
20
involving magnetic resonance
28
Details of apparatus provided for in groups G01R33/44-G01R33/6496
G PHYSICS
01
MEASURING; TESTING
R
MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33
Arrangements or instruments for measuring magnetic variables
20
involving magnetic resonance
44
using nuclear magnetic resonance (NMR)
48
NMR imaging systems
54
Signal processing systems, e.g. using pulse sequences
56
Image enhancement or correction, e.g. subtraction or averaging techniques
563
of moving material, e.g. flow-contrast angiography
Applicants:
REGENTS OF THE UNIVERSITY OF MINNESOTA [US/US]; Morrill Hall 100 Church Street S.E. Minneapolis, MN 55455, US (AllExceptUS)
KUCHARCZYK, John [US/US]; US (UsOnly)
MOSELEY, Michael, E. [US/US]; US (UsOnly)
Inventors:
KUCHARCZYK, John; US
MOSELEY, Michael, E.; US
Agent:
VIKSNINS, Ann, S.; Schwegman, Lundberg, Woessner & Kluth P.O. Box 2938 Minneapolis, MN 55402, US
Priority Data:
08/856,89415.05.1997US
08/857,04315.05.1997US
Title (EN) METHOD AND APPARATUS FOR TARGETED DRUG DELIVERY INTO A LIVING PATIENT USING MAGNETIC RESONANCE IMAGING
(FR) PROCEDE ET APPAREIL D'ADMINISTRATION CIBLEE DE MEDICAMENT A UN PATIENT, METTANT EN OEUVRE UNE IMAGERIE PAR RESONANCE MAGNETIQUE
Abstract:
(EN) The invention is an apparatus and method for targeted drug delivery into a living patient using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at a target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spatial distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
(FR) Cette invention se rapporte à un appareil et à un procédé d'administration ciblée de médicament à un patient au moyen de l'imagerie par résonance magnétique (IRM). Cet appareil et ce procédé servent à l'administration de médicament à tous types de tissu vivant et font appel à l'imagerie par résonance magnétique pour suivre la trace du médicament administré et estimer la vitesse d'administration du médicament. Un dispositif d'administration de médicament par résonance magnétique visible, positionné au niveau d'un site cible (par exemple, en vue d'une administration intracrânienne) administre au tissu (par exemple, au tissu cérébral) une solution médicamenteuse diagnostique ou thérapeutique. La cinétique de distribution spatiale de l'agent médicamenteux injecté ou infusé fait l'objet d'une surveillance quantitative, non invasive, par IRM à diffusion directionnelle de protons dans l'eau permettant d'évaluer l'efficacité de l'administration du médicament au niveau de l'emplacement cible.
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Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0981761JP2001525703 CA2289837AU1998073883