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1. (WO1998051825) PEPTIDES WHICH ENHANCE TRANSPORT OF AN ACTIVE AGENT ACROSS TISSUES AND COMPOSITIONS AND METHODS OF USING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/051825 International Application No.: PCT/US1998/010079
Publication Date: 19.11.1998 International Filing Date: 15.05.1998
Chapter 2 Demand Filed: 15.12.1998
IPC:
A61K 9/16 (2006.01) ,A61K 9/51 (2006.01) ,A61K 47/48 (2006.01) ,C12N 15/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
10
Processes for the isolation, preparation or purification of DNA or RNA
Applicants:
O'MAHONY, Daniel, Joseph [IE/IE]; IE (UsOnly)
ALVAREZ, Vernon, Leon [US/US]; US (UsOnly)
SEVESO, Michela [IT/IE]; IE (UsOnly)
ELAN CORPORATION, PLC [IE/IE]; Lincoln House Lincoln Place Dublin 2, IE (AllExceptUS)
CYTOGEN CORPORATION [US/US]; 600 College Road East CN-5308 Princeton, NJ 08540-5308, US (AllExceptUS)
Inventors:
O'MAHONY, Daniel, Joseph; IE
ALVAREZ, Vernon, Leon; US
SEVESO, Michela; IE
Agent:
SEVERSON, Mary, L.; Elan Pharmaceutical Research Corp. 1300 Gould Drive Gainesville, GA 30504, US
Priority Data:
08/857,04615.05.1997US
Title (EN) PEPTIDES WHICH ENHANCE TRANSPORT OF AN ACTIVE AGENT ACROSS TISSUES AND COMPOSITIONS AND METHODS OF USING THE SAME
(FR) PEPTIDES FAVORISANT LE TRANSPORT D'UN AGENT ACTIF DANS LES TISSUS, COMPOSITIONS LES RENFERMANT ET LEURS PROCEDES D'UTILISATION
Abstract:
(EN) Targeting agents that are capable of permitting or facilitating transport of an active agent through a human or animal gastro-intestinal tissue. These targeting agents are peptides or their derivatives (e.g., fragments) and peptidomimetics thereof, and the nucleotide sequences coding for the peptides and derivatives. The targeting agents have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Therapeutic methods of administration, pharmaceutical compositions and formulations based on the targeting agent peptides are also provided. Preferably, the active agent is a drug or drug-containing nano- or microparticle.
(FR) L'invention concerne des agents de ciblage permettant ou facilitant le transport d'un agent actif dans des tissus gastro-intestinaux humains ou animaux. Ces agents de ciblage sont des peptides, ou leurs dérivés (par exemple des fragments) et leur peptidomimétique, ainsi que les séquences codant ces peptides et leurs dérivés. L'utilisation de ces agents de ciblage facilite le transport d'agents actifs de la lumière du tractus gastro-intestinal à l'ensemble du système cardio-vasculaire, et/ou cible lesdits agents actifs vers ledit tractus gastro-intestinal. L'invention concerne également des procédés d'administration thérapeutiques ainsi que des compositions et des formulations pharmaceutiques à base des peptides agents de ciblage. L'agent actif est de préférence un médicament, ou une microparticule ou une nanoparticule renfermant un médicament.
Designated States: AL, AU, BB, BG, BR, CA, CN, CU, EE, GE, HU, IL, IS, JP, KP, KR, LK, LT, LV, MK, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TR, TT, UA, US, VN
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)