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1. (WO1998051824) REAGENTS AND METHODS USEFUL FOR DETECTING DISEASE OF THE URINARY TRACT

Pub. No.:    WO/1998/051824    International Application No.:    PCT/US1998/009972
Publication Date: Fri Nov 20 00:59:59 CET 1998 International Filing Date: Sat May 16 01:59:59 CEST 1998
IPC: C07K 14/47
C07K 16/18
C12Q 1/68
G01N 33/68
Applicants: ABBOTT LABORATORIES
Inventors: BILLING-MEDEL, Patricia, A.
COHEN, Maurice
COLPITTS, Tracey, L.
FRIEDMAN, Paula, N.
GRANADOS, Edward, N.
HODGES, Steven, C.
KLASS, Michael, R.
KRATOCHVIL, Jon, D.
ROBERTS-RAPP, Lisa
RUSSELL, John, C.
STROUPE, Stephen, D.
Title: REAGENTS AND METHODS USEFUL FOR DETECTING DISEASE OF THE URINARY TRACT
Abstract:
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as UT116 and transcribed from urinary tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to UT116-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific UT116 polypeptide, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.