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1. (WO1998051824) REAGENTS AND METHODS USEFUL FOR DETECTING DISEASE OF THE URINARY TRACT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051824 International Application No.: PCT/US1998/009972
Publication Date: 19.11.1998 International Filing Date: 15.05.1998
Chapter 2 Demand Filed: 02.11.1998
IPC:
C07K 14/47 (2006.01) ,C07K 16/18 (2006.01) ,C12Q 1/68 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
ABBOTT LABORATORIES [US/US]; 100 Abbott Park Road Abbott Park, IL 60064-3500, US
Inventors:
BILLING-MEDEL, Patricia, A.; US
COHEN, Maurice; US
COLPITTS, Tracey, L.; US
FRIEDMAN, Paula, N.; US
GRANADOS, Edward, N.; US
HODGES, Steven, C.; US
KLASS, Michael, R.; US
KRATOCHVIL, Jon, D.; US
ROBERTS-RAPP, Lisa; US
RUSSELL, John, C.; US
STROUPE, Stephen, D.; US
Agent:
WEINSTOCK, Steven, F.; Abbott Laboratories D-377/AP6D 100 Abbott Park Road Abbott Park, IL 60064-3500 , US
Priority Data:
08/856,65215.05.1997US
Title (EN) REAGENTS AND METHODS USEFUL FOR DETECTING DISEASE OF THE URINARY TRACT
(FR) REACTIFS ET PROCEDES UTILES AU DEPISTAGE DE MALADIES DU TRACTUS URINAIRE
Abstract:
(EN) A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as UT116 and transcribed from urinary tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to UT116-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific UT116 polypeptide, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.
(FR) Cette invention se rapporte à un ensemble de séquences d'ADNc contiguës et à recouvrement partiel, ainsi qu'aux polypeptides codés par ces séquences, désignées sous le terme UT116 et transcrites à partir de tissu du tractus urinaire. Ces séquences s'avèrent utiles s'agissant de déceler, de diagnostiquer, d'effectuer la stadification, de contrôler, de pronostiquer, de former des images in vivo, de prévenir ou de traiter des maladies et des troubles du tractus urinaire, tels que le cancer du tractus urinaire, ou de déterminer la prédisposition d'un sujet à ces maladies ou troubles. Cette invention se rapporte également à des anticorps qui se lient de manière spécifique aux polypeptides ou protéines codés par UT116, et à des agonistes ou à des inhibiteurs qui empêchent l'action du polypeptide de UT116 spécifique d'un tissu, lesdites molécules s'avérant utiles au traitement des maladies, des tumeurs ou des métastases du tractus urinaire.
Designated States: CA, JP
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)