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1. (WO1998051805) REAGENTS AND METHODS USEFUL FOR DETECTING DISEASES OF THE PROSTATE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051805 International Application No.: PCT/US1998/010041
Publication Date: 19.11.1998 International Filing Date: 15.05.1998
Chapter 2 Demand Filed: 02.10.1998
IPC:
C07K 14/47 (2006.01) ,C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
ABBOTT LABORATORIES [US/US]; 100 Abbott Park Road Abbott Park, IL 60064-3500, US
Inventors:
BILLING-MEDEL, Patricia, A.; US
COHEN, Maurice; US
COLPITTS, Tracey, L.; US
FRIEDMAN, Paula, N.; US
GORDON, Julian; US
GRANADOS, Edward, N.; US
HODGES, Steven, C.; US
KLASS, Michael, R.; US
KRATOCHVIL, Jon, D.; US
ROBERTS-RAPP, Lisa; US
RUSSELL, John, C.; US
STROUPE, Stephen, D.; US
Agent:
WEINSTOCK, Steven, F.; Abbott Laboratories D-377/AP6D 100 Abbott Park Road Abbott Park, IL 60064-3500 , US
Priority Data:
08/856,65315.05.1997US
Title (EN) REAGENTS AND METHODS USEFUL FOR DETECTING DISEASES OF THE PROSTATE
(FR) REACTIFS ET PROCEDES UTILES POUR DETECTER DES MALADIES DE LA PROSTATE
Abstract:
(EN) A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS116 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS116-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS116 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
(FR) Série de séquences d'ADNc contiguës et partiellement chevauchantes et polypeptides codés par lesdites séquences, désignés par PS116 et transcrits à partir de tissus prostatiques. Lesdites séquences sont utiles pour détecter, diagnostiquer, établir le stade, surveiller, pronostiquer, produire des images in vivo, empêcher ou traiter des maladies ou états pathologiques de la prostate, tels que le cancer de la prostate, ou déterminer la prédisposition d'un sujet à développer lesdites maladies. La présente invention concerne également des anticorps qui se lient spécifiquement au polypeptide ou à la protéine codés par PS116, ainsi que des agonistes et inhibiteurs qui empêchent l'action du polypeptide PS116 spécifique à des tissus, ces molécules étant utiles pour traiter des maladies, tumeurs ou métastases de la prostate.
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Designated States: CA, JP
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)