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1. (WO1998051787) GENE CONSTRUCT ENCODING A HETEROLOGOUS PRODRUG-ACTIVATING ENZYME AND A CELL TARGETING MOIETY

Pub. No.:    WO/1998/051787    International Application No.:    PCT/GB1998/001294
Publication Date: Fri Nov 20 00:59:59 CET 1998 International Filing Date: Wed May 06 01:59:59 CEST 1998
IPC: A61K 38/00
A61K 47/48
A61K 48/00
C07K 16/30
C12N 9/48
Applicants: ZENECA LIMITED
EMERY, Stephen, Charles
BLAKEY, David, Charles
Inventors: EMERY, Stephen, Charles
BLAKEY, David, Charles
Title: GENE CONSTRUCT ENCODING A HETEROLOGOUS PRODRUG-ACTIVATING ENZYME AND A CELL TARGETING MOIETY
Abstract:
The invention provides a gene construct encoding a cell targeting moiety and a heterologous prodrug activating enzyme for use as a medicament in a mammalian host wherein the gene construct is capable of expressing the cell targeting moiety and enzyme as a conjugate within a target cell in the mammalian host and wherein the conjugate is directed to leave the cell thereafter for selective localisation at a cell surface antigen recognised by the cell targeting moiety.