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Machine translation
1. (WO1998051787) GENE CONSTRUCT ENCODING A HETEROLOGOUS PRODRUG-ACTIVATING ENZYME AND A CELL TARGETING MOIETY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/051787    International Application No.:    PCT/GB1998/001294
Publication Date: 19.11.1998 International Filing Date: 05.05.1998
Chapter 2 Demand Filed:    02.11.1998    
IPC:
A61K 38/00 (2006.01), A61K 47/48 (2006.01), A61K 48/00 (2006.01), C07K 16/30 (2006.01), C12N 9/48 (2006.01)
Applicants: ZENECA LIMITED [GB/GB]; 15 Stanhope Gate, London W1Y 6LN (GB) (For All Designated States Except US).
EMERY, Stephen, Charles [GB/GB]; (GB) (For US Only).
BLAKEY, David, Charles [GB/GB]; (GB) (For US Only)
Inventors: EMERY, Stephen, Charles; (GB).
BLAKEY, David, Charles; (GB)
Agent: GILES, Allen, Frank; Zeneca Pharmaceuticals, Intellectual Property Dept., Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG (GB)
Priority Data:
9709421.3 10.05.1997 GB
Title (EN) GENE CONSTRUCT ENCODING A HETEROLOGOUS PRODRUG-ACTIVATING ENZYME AND A CELL TARGETING MOIETY
(FR) COMPOSES CHIMIQUES
Abstract: front page image
(EN)The invention provides a gene construct encoding a cell targeting moiety and a heterologous prodrug activating enzyme for use as a medicament in a mammalian host wherein the gene construct is capable of expressing the cell targeting moiety and enzyme as a conjugate within a target cell in the mammalian host and wherein the conjugate is directed to leave the cell thereafter for selective localisation at a cell surface antigen recognised by the cell targeting moiety.
(FR)L'invention concerne une construction génique qui code un groupe de ciblage cellulaire et une enzyme hétérologue activatrice de prodrogue, et qui peut être utilisée comme médicament chez un mammifère hôte. Cette construction est capable d'exprimer le groupe de ciblage cellulaire et l'enzyme sous la forme d'un conjugué dans une cellule cible du mammifère hôte. Le conjugué est dirigé de façon à sortir ensuite de la cellule afin de se placer sélectivement au niveau d'un antigène de la surface cellulaire reconnu par le groupe de ciblage cellulaire.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)