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1. (WO1998051781) TRANSGENIC ANIMAL EXPRESSING NON-NATIVE WILD-TYPE AND FAMILIAL ALZHEIMER'S DISEASE MUTANT PRESENILIN 1 PROTEIN ON NATIVE PRESENILIN 1 NULL BACKGROUND
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051781 International Application No.: PCT/US1998/009709
Publication Date: 19.11.1998 International Filing Date: 13.05.1998
Chapter 2 Demand Filed: 14.12.1998
IPC:
A61K 49/00 (2006.01) ,C07K 14/47 (2006.01) ,C12N 15/85 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
Applicants:
MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
JOHNS HOPKINS UNIVERSITY [US/US]; 720 Rutland Avenue Baltimore, MD 21205, US (AllExceptUS)
ZHENG, Hui [CN/US]; US (UsOnly)
QIAN, Su [CN/US]; US (UsOnly)
VAN DER PLOEG, Leonardus, H., T. [NL/US]; US (UsOnly)
WONG, Philip, C. [CA/US]; US (UsOnly)
SISODIA, Sangram, S. [US/US]; US (UsOnly)
JIANG, Ping [CN/US]; US (UsOnly)
Inventors:
ZHENG, Hui; US
QIAN, Su; US
VAN DER PLOEG, Leonardus, H., T.; US
WONG, Philip, C.; US
SISODIA, Sangram, S.; US
JIANG, Ping; US
Agent:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data:
60/046,48814.05.1997US
60/078,46518.03.1998US
Title (EN) TRANSGENIC ANIMAL EXPRESSING NON-NATIVE WILD-TYPE AND FAMILIAL ALZHEIMER'S DISEASE MUTANT PRESENILIN 1 PROTEIN ON NATIVE PRESENILIN 1 NULL BACKGROUND
(FR) ANIMAL TRANSGENIQUE EXPRIMANT UNE PROTEINE PRESENILINE 1 MUTANTE NON NATIVE DE TYPE SAUVAGE DE LA MALADIE D'ALZHEIMER FAMILIALE DANS UN CONTEXTE DEPOURVU DE PRESENILINE 1 NATIVE
Abstract:
(EN) The present invention relates to a transgenic non-human animal embryo laking native presenilin (1) and a transgenic non-human animal having only a non-native presenilin (1). The transgenic animals and cells derived therefrom can be used in the study of the expression pattern, activity and modulators of presenilin (1), in the study of the role of presenilin (1) in Alzheimer's Disease and in the study of disorders of the central nervous system.
(FR) La présente invention concerne un embryon animal transgénique exempt de préséniline 1 native et un animal transgénique ne possédant qu'une préséniline 1 non native. Les animaux et les cellules transgéniques qui en résultent peuvent être utilisés pour l'étude des schémas d'expression, de l'activité et des modulateurs de la préséniline 1, pour l'étude du rôle joué par la préséniline 1 dans la maladie d'Alzheimer et pour l'étude des troubles du système nerveux central.
Designated States: CA, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0981602JP2001514528 CA2290039