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1. (WO1998051704) PEPTIDES PROMOTING THE ACTIVATION OF LATENT TGF-$g(b) AND METHOD FOR SCREENING TGF-$g(b) ACTIVITY REGULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/051704 International Application No.: PCT/JP1998/002089
Publication Date: 19.11.1998 International Filing Date: 12.05.1998
IPC:
A61K 38/00 (2006.01) ,C07K 14/47 (2006.01) ,C07K 14/495 (2006.01) ,G01N 33/74 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
495
Transforming growth factor (TGF)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74
involving hormones
Applicants:
YAMASAKI, Motoo [JP/JP]; JP (UsOnly)
SHIBATA, Kenji [JP/JP]; JP (UsOnly)
SATO, Yasufumi [JP/JP]; JP (UsOnly)
KYOWA HAKKO KOGYO CO., LTD. [JP/JP]; 6-1, Ohtemachi 1-chome Chiyoda-ku Tokyo 100-8185, JP (AllExceptUS)
Inventors:
YAMASAKI, Motoo; JP
SHIBATA, Kenji; JP
SATO, Yasufumi; JP
Priority Data:
9/12068312.05.1997JP
Title (EN) PEPTIDES PROMOTING THE ACTIVATION OF LATENT TGF-$g(b) AND METHOD FOR SCREENING TGF-$g(b) ACTIVITY REGULATORS
(FR) PEPTIDES FAVORISANT L'ACTIVATION DE TGF-$g(b) LATENT ET PROCEDE DE SELECTION DE REGULATEURS A ACTIVITE DE TGF-$g(b)
Abstract:
(EN) Peptides represented by the following general formula (I) and having the activity of promoting the liberation of active TGF-$g(b) from latent TGF-$g(b) or the activity of promoting the binding of latent TGF-$g(b) to cell membrane; a method for screening compounds for preventing or treating diseases in which TGF-$g(b) participates by assaying the above activities; and the compounds thus obtained. The peptides and compounds described above are useful as remedies or preventives for cancer, diabetic retinitis, atherosclerosis, etc. General formula (I): R1-A-R2, wherein R1 represents hydrogen, optionally substituted alkanoyl, etc.; R2 represents hydroxy or optionally substituted alkoxy or amino; and A represents a sequence selected from among the partial sequences of the TGF-$g(b) precursor sequence.
(FR) Cette invention se rapporte à des peptides qui sont représentés par la formule générale (I) et qui ont le pouvoir de favoriser la libération de TGF-$g(b) (facteur de croissance transformant bêta) actif à partir de TGF-$g(b) latent ou qui ont le pouvoir de favoriser la fixation de TGF-$g(b) latent sur la membrane des cellules; à un procédé de sélection de composés en vue de prévenir ou de traiter les maladies dans lesquelles le TGF-$g(b) joue un rôle, par dosage de ces activités; et aux composés ainsi obtenus. Les peptides et les composés décrits ci-dessus sont utiles comme médicaments ou comme agents de prévention contre le cancer, les rétinites diabétiques et l'athérosclérose, notamment. Dans la formule (I), R1 représente hydrogène, alcanoyle éventuellement substitué, etc; R2 représente hydroxy ou alcoxy ou amino éventuellement substitué et A représente une séquence choisie parmi les séquences partielles de la séquence précurseur de TGF-$g(b).
Designated States: AU, BG, BR, CA, CN, CZ, HU, IL, JP, KR, MX, NO, NZ, PL, RO, SG, SI, SK, UA, US, VN
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)