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1. (WO1998051701) TUMOR SURFACE PROTEIN AND ITS COMPLEMENTARY SURFACE RECEPTOR ON NAIVE NATURAL KILLER CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051701 International Application No.: PCT/US1998/010021
Publication Date: 19.11.1998 International Filing Date: 15.05.1998
Chapter 2 Demand Filed: 03.12.1998
IPC:
C07K 14/47 (2006.01) ,C07K 14/705 (2006.01) ,C07K 16/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK [US/US]; P.O. Box 9 Albany, NY 12201-0009, US (AllExceptUS)
NORIN, Allen, J. [US/US]; US (UsOnly)
Inventors:
NORIN, Allen, J.; US
Agent:
BARON, Ronald, J.; Hoffmann & Baron, LLP 350 Jericho Turnpike Jericho, NY 11753, US
Priority Data:
60/046,55315.05.1997US
Title (EN) TUMOR SURFACE PROTEIN AND ITS COMPLEMENTARY SURFACE RECEPTOR ON NAIVE NATURAL KILLER CELLS
(FR) PROTEINE DE SURFACE DE CELLULE TUMORALE ET SON RECEPTEUR DE SURFACE COMPLEMENTAIRE SUR DES LYMPHOCYTES TUEURS NATURELS NAIFS
Abstract:
(EN) The invention is an isolated and purified cell surface protein of about 38.5 kD expressed by tumor cells susceptible to cell-mediated lysis by naive Natural Killer (NK) cells. The invention also includes an isolated and purified membrane protein of about 70 kD which is characteristically expressed by naive Natural Killer (NK) cells and which binds to tumor cells that are susceptible to natural killer (NK) cell-mediated lysis. The 70 kD protein binds to the 38.5 kD tumor cell surface protein. The invention also includes nucleic acids containing gene fragments and/or genes for the cell surface proteins, and amino acid sequences. The invention further includes antibodies to the proteins and to fragments of the proteins. Diagnostic methods for identifying tumor cells susceptible to natural killer (NK) cell-mediated lysis are also included. The invention also includes methods for determining the number of natural killer (NK) cells in a biological sample.
(FR) Protéine de surface cellulaire isolée et purifiée d'environ 38,5 kD exprimée par des cellules tumorales sensibles à la lyse induite par les lymphocytes tueurs naturels (NK) naïfs. La présente invention concerne également une protéine de membrane isolée et purifiée d'environ 70 kD qui est exprimée de manière caractéristique par les lymphocytes NK jeunes et qui se lie aux cellules tumorales sensibles à la lyse induite par les lymphocytes NK. La protéine de 70 kD se lie à la protéine de surface de cellule tumorale de 38,5 kD. La présente invention concerne encore des acides nucléiques contenant des fragments de gène et/ou des gènes pour lesdites protéines de surface cellulaire, ainsi que des séquences d'acides aminés. Elle concerne en outre des anticorps contre les protéines ou les fragments des protéines. Elle concerne enfin des méthodes diagnostiques permettant d'identifier des cellules tumorales sensibles à la lyse induite par des lymphocytes tueurs naturels, ainsi que des méthodes permettant de déterminer le nombre de lymphocytes tueurs naturels dans un échantillon biologique.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1003766AU1998074920