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1. (WO1998051700) RETROVIRAL ENVELOPES HAVING MODIFIED HYPERVARIABLE POLYPROLINE REGIONS

Pub. No.:    WO/1998/051700    International Application No.:    PCT/US1998/009718
Publication Date: Fri Nov 20 00:59:59 CET 1998 International Filing Date: Thu May 14 01:59:59 CEST 1998
IPC: C12N 15/867
Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA
ANDERSON, W., French
WU, Bonnie, Weimin
Inventors: ANDERSON, W., French
WU, Bonnie, Weimin
Title: RETROVIRAL ENVELOPES HAVING MODIFIED HYPERVARIABLE POLYPROLINE REGIONS
Abstract:
A retroviral vector particle having a modified retroviral envelope polypeptide. The retroviral envelope polypeptide includes the hypervariable polyproline region, or hinge region, and the hypervariable polyproline region, or hinge region is modified to include a heterologous protein or peptide, such as a targeting polypeptide including a binding region which binds to a ligand. Such a retroviral vector may be 'targeted' to various cells for delivery of genetic material to such cells.