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1. (WO1998051700) RETROVIRAL ENVELOPES HAVING MODIFIED HYPERVARIABLE POLYPROLINE REGIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051700 International Application No.: PCT/US1998/009718
Publication Date: 19.11.1998 International Filing Date: 13.05.1998
Chapter 2 Demand Filed: 07.12.1998
IPC:
C12N 15/867 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
867
Retroviral vectors
Applicants:
UNIVERSITY OF SOUTHERN CALIFORNIA [US/US]; Suite 313 3716 South Hope Street Los Angeles, CA 90033, US (AllExceptUS)
ANDERSON, W., French [US/US]; US (UsOnly)
WU, Bonnie, Weimin [CN/US]; US (UsOnly)
Inventors:
ANDERSON, W., French; US
WU, Bonnie, Weimin; US
Agent:
LILLIE, Raymond, J. ; Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein 6 Becker Farm Road Roseland, NJ 07068, US
Priority Data:
08/856,07414.05.1997US
Title (EN) RETROVIRAL ENVELOPES HAVING MODIFIED HYPERVARIABLE POLYPROLINE REGIONS
(FR) ENVELOPPES RETROVIRALES A REGIONS POLYPROLINE HYPERVARIABLES MODIFIEES
Abstract:
(EN) A retroviral vector particle having a modified retroviral envelope polypeptide. The retroviral envelope polypeptide includes the hypervariable polyproline region, or hinge region, and the hypervariable polyproline region, or hinge region is modified to include a heterologous protein or peptide, such as a targeting polypeptide including a binding region which binds to a ligand. Such a retroviral vector may be 'targeted' to various cells for delivery of genetic material to such cells.
(FR) L'invention concerne une particule de vecteur rétroviral possédant une enveloppe polypeptidique rétrovirale modifiée. L'enveloppe polypeptidique rétrovirale comporte la région polyproline hypervariable, ou région charnière, laquelle est modifiée de manière à comporter une protéine ou un peptide hétérologue, tel qu'un polypeptide de ciblage dont une région de liaison se lie à un ligand. Un vecteur rétroviral de ce type peut être 'ciblé' vers diverses cellules afin de leur apporter du matériel génétique.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998073836