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1. (WO1998051686) N-TRIAZOLYL-2-INDOLECARBOXAMIDES AND THEIR USE AS CCK-A AGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051686 International Application No.: PCT/FR1998/000905
Publication Date: 19.11.1998 International Filing Date: 06.05.1998
Chapter 2 Demand Filed: 21.10.1998
IPC:
C07D 249/14 (2006.01) ,C07D 403/12 (2006.01) ,C07D 403/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
249
Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02
not condensed with other rings
08
1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
14
Nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
Applicants:
SANOFI-SYNTHELABO [FR/FR]; 174, avenue de France F-75013 Paris, FR (AllExceptUS)
BIGNON, Eric [FR/FR]; FR (UsOnly)
BRAS, Jean-Pierre [FR/FR]; FR (UsOnly)
DE COINTET, Paul [FR/FR]; FR (UsOnly)
DESPEYROUX, Pierre [FR/FR]; FR (UsOnly)
FREHEL, Daniel [FR/FR]; FR (UsOnly)
GULLY, Danielle [FR/FR]; FR (UsOnly)
Inventors:
BIGNON, Eric; FR
BRAS, Jean-Pierre; FR
DE COINTET, Paul; FR
DESPEYROUX, Pierre; FR
FREHEL, Daniel; FR
GULLY, Danielle; FR
Agent:
SANOFI-SYNTHELABO; Département Brevets 174, avenue de France F-75013 Paris, FR
Common
Representative:
SANOFI-SYNTHELABO; Département Brevets 174, avenue de France F-75013 Paris, FR
Priority Data:
97/0585013.05.1997FR
Title (EN) N-TRIAZOLYL-2-INDOLECARBOXAMIDES AND THEIR USE AS CCK-A AGONISTS
(FR) N-TRIAZOLYL-2-INDOLECARBOXAMIDES ET LEUR UTILISATION COMME AGONISTES DE CCK-A
Abstract:
(EN) The invention concerns compounds of formula (I) in which R1, R4, X1, X2, X3, X4, Y1, Y2 and Y3 are as defined in claim 1. These compounds have partial or total agonist activity of CCK-A receptors and are useful for treating eating problems, obesity, tardive dyskinesia and disorders of the gastrointestinal sphere.
(FR) L'invention a pour objet des composés de formule (I) dans laquelle R1, R4, X1, X2, X3, X4, Y1, Y2 et Y3 sont tels que définis à la revendication 1. Ces composés possédent une activité agoniste partielle ou totale des récepteurs CCK-A, et sont utiles dans le traitement des désordres alimentaires, de l'obésité, de la dyskinésie tardive et des troubles de la sphère gastrointestinale.
Designated States: AU, BR, BY, CA, CN, CZ, EE, HU, ID, IL, IS, JP, KR, LK, LT, LV, MX, NO, NZ, PL, RU, SG, SI, SK, TR, UA, US, VN, YU
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
CZPV1999-4006IS5235NO19995513SK154299TR1999/02795YUP-579/99
MXPA/a/1999/010450KR1020010012541SG68857VN4699ZA1998/03997IL132903
ES2190081UY0001024997EP0984960RU02175323EE9900524JP2001524980
CN1263528CA2289573DE000069811223NZ500637AU1998076599FR2763337
MYPI 98002127ID022.911