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1. (WO1998051678) CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1$g(a) (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051678 International Application No.: PCT/US1998/010062
Publication Date: 19.11.1998 International Filing Date: 15.05.1998
Chapter 2 Demand Filed: 11.12.1998
IPC:
C07C 401/00 (2006.01) ,C07D 303/14 (2006.01) ,C07D 307/33 (2006.01) ,C07D 309/04 (2006.01) ,C07D 309/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
401
Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
303
Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
02
Compounds containing oxirane rings
12
with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
14
by free hydroxyl radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
26
having one double bond between ring members or between a ring member and a non-ring member
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
32
Oxygen atoms
33
in position 2, the oxygen atom being in its keto or unsubstituted enol form
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
309
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
02
having no double bonds between ring members or between ring members and non-ring members
04
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
309
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
02
having no double bonds between ring members or between ring members and non-ring members
04
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
06
Radicals substituted by oxygen atoms
Applicants:
WOMEN & INFANTS HOSPITAL [US/US]; 101 Dudley Street Providence, RI 02905, US
Inventors:
REDDY, Satayanarayana, G.; US
Agent:
HANLEY, Elizabeth, A. ; Lahive & Cockfield, LLP 28 State Street Boston, MA 02109, US
Priority Data:
60/046,69016.05.1997US
Title (EN) CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1$g(a) (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF
(FR) COMPOSES DE VITAMINE D3 A ETHER CYCLIQUE ET COMPOSES DE 1$g(a)(OH)3-EPI-VITAMINE D3, ET UTILISATION DESDITS COMPOSES
Abstract:
(EN) Novel cyclic ether vitamin D3 compounds having a cyclic ether side chain are disclosed. These compounds were first identified as metabolites of 3-epi vitamin D3 produced via a tissue-specific metabolic pathway which catalyzes the formation of a cyclic ether structure. Also disclosed are 1$g(a)(OH) 3-epi vitamin D3 compounds, which are produced via the epimerization of a 3-$g(b)-hydroxyl group of 1 $g(a)(OH) vitamin D3 precursor $i(in vivo). The vitamin D3 compounds of the present invention can be used as substitutes for natural and synthetic vitamin D3 compounds.
(FR) Nouveaux composés de vitamine D3 comportant une chaîne latérale d'éther cyclique. Lesdits composés ont d'abord été identifiés en tant que métabolites de formes 3-épi de vitamine D3 produits via une voie métabolique spécifique à des tissus qui catalyse la formation d'une structure d'éther cyclique. La présente invention concerne également des composés de 1$g(a)(OH)3-épi-vitamine D3 qui sont produits via l'épimérisation d'un groupe 3-$g(b)-hydroxyle d'un précurseur sous forme de 1$g(a)(OH)vitamine D3 $i(in vivo). Lesdits composés de vitamine D3 peuvent être utilisés comme substituts de composés de vitamine D3 naturelle et synthétique.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0981523JP2002505668 CA2289209AU1998074936AU2002035640