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1. (WO1998051350) METHODS OF TREATMENT USING NBS-1, ANTIBODIES AND PROTEINS THERETO, AND USES OF THE ANTIBODIES

Pub. No.:    WO/1998/051350    International Application No.:    PCT/US1998/009516
Publication Date: Fri Nov 20 00:59:59 CET 1998 International Filing Date: Wed May 13 01:59:59 CEST 1998
IPC: C07K 14/47
C07K 16/18
Applicants: DANA-FARBER CANCER INSTITUTE
Inventors: KAELIN, William
JOST, Christine
Title: METHODS OF TREATMENT USING NBS-1, ANTIBODIES AND PROTEINS THERETO, AND USES OF THE ANTIBODIES
Abstract:
Antibodies that will specifically bind to NBS-1 are described. It is also shown that NBS-1 will interact with p53 responsive elements in a p53 promoter. Thus, NBS-1 can be used in subjects having a p53-dependent tumor to inhibit growth of that tumor.