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1. (WO1998051350) METHODS OF TREATMENT USING NBS-1, ANTIBODIES AND PROTEINS THERETO, AND USES OF THE ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/051350 International Application No.: PCT/US1998/009516
Publication Date: 19.11.1998 International Filing Date: 12.05.1998
Chapter 2 Demand Filed: 10.12.1998
IPC:
C07K 14/47 (2006.01) ,C07K 16/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
Applicants:
DANA-FARBER CANCER INSTITUTE [US/US]; 44 Binney Street Boston, MA 02115, US
Inventors:
KAELIN, William; US
JOST, Christine; US
Agent:
EISENSTEIN, Ronald, I. ; Dike, Bronstein, Roberts & Cushman, LLP 130 Water Street Boston, MA 02109-4280, US
Priority Data:
60/046,20712.05.1997US
Title (EN) METHODS OF TREATMENT USING NBS-1, ANTIBODIES AND PROTEINS THERETO, AND USES OF THE ANTIBODIES
(FR) METHODES DE TRAITEMENT AU MOYEN DE NBS-1, D'ANTICORPS ET DE PROTEINES DIRIGES CONTRE CE DERNIER ET UTILISATIONS DE CES ANTICORPS
Abstract:
(EN) Antibodies that will specifically bind to NBS-1 are described. It is also shown that NBS-1 will interact with p53 responsive elements in a p53 promoter. Thus, NBS-1 can be used in subjects having a p53-dependent tumor to inhibit growth of that tumor.
(FR) Anticorps se liant spécifiquement au gène HBS-1. Il est également démontré que NBS-1 interagit avec les éléments réceptifs au p53 dans un promoteur de p53. Par conséquent NBS-1 peut être utilisé pour inhiber la croissance tumorale chez des sujets présentant une tumeur liée à p53.
Designated States: AU, CA, JP
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)