Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO1998051346) HUMAN TUMOR NECROSIS FACTOR RECEPTOR-LIKE 2 (TR2) ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/051346 International Application No.: PCT/US1998/009744
Publication Date: 19.11.1998 International Filing Date: 12.05.1998
Chapter 2 Demand Filed: 02.12.1998
IPC:
A61K 38/00 (2006.01) ,C07K 16/28 (2006.01) ,G01N 33/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
HARROP, Jeremy, A. [GB/US]; US (UsOnly)
HOLMES, Stephen, D. [GB/GB]; GB (UsOnly)
REDDY, Manjula, P. [IN/US]; US (UsOnly)
TRUNEH, Alemseged [US/US]; US (UsOnly)
SMITHKLINE BEECHAM CORPORATION [US/US]; One Franklin Plaza Philadelphia, PA 19103, US (AllExceptUS)
SMITHKLINE BEECHAM PLC [GB/GB]; New Horizons Court Great West Road Brentford Middlesex TW8 9EP, GB (AllExceptUS)
Inventors:
HARROP, Jeremy, A.; US
HOLMES, Stephen, D.; GB
REDDY, Manjula, P.; US
TRUNEH, Alemseged; US
Agent:
HAN, William, T. ; SmithKline Beecham Corporation Corporate Intellectual Property, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US
Priority Data:
60/046,24912.05.1997US
Title (EN) HUMAN TUMOR NECROSIS FACTOR RECEPTOR-LIKE 2 (TR2) ANTIBODIES
(FR) ANTICORPS CONTRE LE RECEPTEUR DE TYPE 2 (TR2) DU FACTEUR DE NECROSE DES TUMEURS HUMAIN
Abstract:
(EN) The present invention relates to antibodies to novel members of the Tumor Necrosis Factor (TNF) receptor family called TR2 receptor and their uses in pathological conditions. Hybridoma cell lines producing such mAbs, methods of in vivo imaging of pathological conditions, and methods of treating and diagnosing pathological conditions, caused by abnormal functioning, production or metabolism of TR2 receptors are also provided. In vitro assays for detecting the presence of TR2 and for evaluating the binding affinity of a test compound are also described.
(FR) La présente invention concerne des anticorps dirigés contre de nouveaux membres de la famille des récepteurs du facteur de nécrose des tumeurs (TNF) appelés récepteurs TR2 et leur utilisations dans des états pathologiques. L'invention concerne également des lignées de cellules d'hybridomes produisant de tels anticorps monoclonaux, des méthodes d'imagerie in vivo d'un état pathologique, et des méthodes thérapeutiques et diagnostiques concernant les états pathologiques provoqués par un fonctionnement, une production ou un métabolisme anormal des récepteurs TR2. L'invention concerne enfin des analyses in vitro permettant de détecter la présence de TR2 et d'évaluer l'affinité de liaison d'un composé analysé.
Designated States: CA, JP, US
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)