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1. (WO1998051344) SUPPRESSION OF TUMOR NECROSIS FACTOR ALPHA AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/051344    International Application No.:    PCT/GB1998/001343
Publication Date: 19.11.1998 International Filing Date: 12.05.1998
Chapter 2 Demand Filed:    19.11.1998    
IPC:
A61K 31/00 (2006.01), A61K 39/395 (2006.01), C07K 16/24 (2006.01)
Applicants: THE KENNEDY INSTITUTE OF RHEUMATOLOGY [GB/GB]; One Aspenlea Road, Hammersmith, London W6 8LH (GB)
Inventors: FELDMANN, Marc; (GB).
MAINI, Ravinder, Nath; (US).
PALEOLOG, Ewa, Maria; (GB)
Agent: HARVEY, David, Gareth; Graham Watt & Co., Riverhead, Sevenoaks, Kent TN13 2BN (GB)
Priority Data:
08/854,881 12.05.1997 US
Title (EN) SUPPRESSION OF TUMOR NECROSIS FACTOR ALPHA AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN THERAPY
(FR) SUPPRESSION THERAPEUTIQUE DU FACTEUR DE NECROSE TUMORALE ALPHA ET DU FACTEUR DE CROISSANCE DES CELLULES ENDOTHELIALES VASCULAIRES
Abstract: front page image
(EN)Methods for treating and/or preventing a TNF-mediated disease in an individual are disclosed. Also disclosed are compositions comprising a TNF$g(a) antagonist and a VEGF antagonist. TNF-mediated diseases include rheumatoid arthritis, Crohn's disease, and acute and chronic immune diseases associated with transplantation.
(FR)L'invention concerne des procédés permettant de traiter et/ou d'empêcher une maladie associée au facteur de nécrose tumorale (TNF) chez un individu. L'invention concerne également des compositions contenant un antagoniste du TNF$g(a) et un antagoniste du facteur de croissance des cellules endothéliales vasculaires (VEGF). Parmi les maladies médiées par le TNF on trouve la polyarthrite rhumatoïde, la maladie de Crohn ainsi que des troubles immunologiques aigus et chroniques associés à une greffe.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)