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1. (WO1998051341) ANTIGEN-mPEG CONJUGATES SUPPRESS HUMORAL AND CELL MEDIATED IMMUNE RESPONSES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051341 International Application No.: PCT/US1998/009786
Publication Date: 19.11.1998 International Filing Date: 14.05.1998
Chapter 2 Demand Filed: 14.12.1998
IPC:
A61K 39/00 (2006.01) ,A61K 47/48 (2006.01) ,A61K 48/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
THE UNIVERSITY OF MANITOBA [CA/CA]; Industry Liaison Office Bannatyne Campus 753 McDermot Avenue Winnipeg, Manitoba R3E 0W3, CA (AllExceptUS)
EMORY UNIVERSITY [US/US]; Office of Technology Transfer 2009 Ridgewood Drive Atlanta, GA 30322, US (AllExceptUS)
SEHON, Alec, H. [CA/CA]; CA (UsOnly)
KAPP, Judith, A. [US/US]; US (UsOnly)
LANG, Glen, M. [CA/CA]; CA (UsOnly)
KE, Yong [US/US]; US (UsOnly)
Inventors:
SEHON, Alec, H.; CA
KAPP, Judith, A.; US
LANG, Glen, M.; CA
KE, Yong; US
Agent:
MILLS, Demetra, J.; Antonelli, Terry, Stout & Kraus, LLP Suite 1800 1300 North Seventeenth Street Arlington, VA 22209, US
Priority Data:
60/046,46914.05.1997US
Title (EN) ANTIGEN-mPEG CONJUGATES SUPPRESS HUMORAL AND CELL MEDIATED IMMUNE RESPONSES
(FR) CONJUGUES ANTIGENE-mPEG SUPPRIMANT DES REPONSES IMMUNITAIRES HUMORALES ET A MEDIATION CELLULAIRE
Abstract:
(EN) A method of inducing tolerance to an antigen (Ag) in both humoral and cell-mediated immune responses by administering an effective amount of an immunosuppressive Ag(mPEG) conjugate. Methods of treating allergies, autoimmune diseases and preventing an immune rejection of organ transplants and DNA transfected cells or cells transfected with a gene therapy vector encoding a foreign protein for gene therapy are also disclosed.
(FR) L'invention concerne une méthode permettant d'induire une tolérance à un antigène (Ag) dans des réponses immunitaires humorales et à médiation cellulaire par administration d'une quantité effective d'un conjugué d'Ag (mPEG) immunosuppresseur. L'invention concerne également des méthodes de traitement d'allergies et d'affections auto-immunes et de prévention d'un rejet immunitaire de transplantations d'organes et de cellules transfectées d'ADN ou de cellules transfectées avec un vecteur de thérapie génique codant une protéine exogène destinée à une thérapie génique.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998074853