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1. (WO1998051337) IMMUNOGENIC COMPOSITIONS TO THE CCK-B/GASTRIN-RECEPTOR AND METHODS FOR THE TREATMENT OF TUMORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051337 International Application No.: PCT/US1998/009957
Publication Date: 19.11.1998 International Filing Date: 12.05.1998
Chapter 2 Demand Filed: 07.12.1998
IPC:
A61K 38/00 (2006.01) ,A61K 39/00 (2006.01) ,C07K 16/30 (2006.01) ,G01N 33/574 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
APHTON CORPORATION [US/US]; Suite 14 26 Harter Avenue P.O. Box 1049 Woodland, CA 95776-1049, US
Inventors:
MICHAELI, Dov; US
CAPLIN, Martyn; GB
WATSON, Susan, A.; GB
GRIMES, Stephen; US
Agent:
DRIVAS, Dimitrios, T. ; White & Case LLP Patent Dept. 1155 Avenue of the Americas New York, NY 10036, US
Priority Data:
60/046,20112.05.1997US
Title (EN) IMMUNOGENIC COMPOSITIONS TO THE CCK-B/GASTRIN-RECEPTOR AND METHODS FOR THE TREATMENT OF TUMORS
(FR) COMPOSITIONS IMMUNOGENES DIRIGEES CONTRE LE RECEPTEUR DE CCK-B/GASTRINE ET PROCEDE DE TRAITEMENT DES TUMEURS
Abstract:
(EN) The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a peptide from the CCK-B/gastrin-receptor conjugated to a spacer and to an immunogenic carrier. The immunogens are capable of inducing antibodies $i(in vivo) which bind to the CCK-B/gastrin-receptor in tumor cells, thereby preventing growth stimulating peptide hormones from binding to the receptors, and inhibiting tumor cell growth. The immunogens also comprise antibodies against the CCK-B/gastrin-receptor for passive immunization. The invention also concerns diagnostic methods for detecting gastrin-dependent tumors $i(in vivo) or from a tissue biopsy using the antibodies of the invention.
(FR) La présente invention se rapporte à des immunogènes, à des compositions immunogènes et à un procédé de traitement des tumeurs liées à la sécrétion de gastrine. Ces immunogènes comportent un peptide du récepteur de CCK-B/gastrine conjugué à un bras espaceur et à un support immunogène. Ces immunogènes sont susceptibles d'induire la création $i(in vivo) d'anticorps qui se lient au récepteur de CCK-B/gastrine dans des cellules tumorales, ce qui empêche les hormones peptidiques de stimulation de la croissance de se lier aux récepteurs, et permet ainsi d'inhiber la croissance des cellules tumorales. Ces immunogènes comportent également des anticorps dirigés contre le récepteur de CCK-B/gastrine aux fins d'immunisation passive. Cette invention se rapporte également à des procédés diagnostiques de détection des tumeurs liées à la sécrétion de gastrine, $i(in vivo) ou à partir de biopsie de tissue, lesdits procédés utilisant les anticorps décrits ci-dessus.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, RO, RU, SD, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1999-3998MXPA/a/1999/010424IL132718BRPI9811264EP0981369JP2007063289
JP2002511066 CN1255860CA2287872NZ500748NZ511550AU1998075740
DK0981369