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1. (WO1998051336) TARGETED DELIVERY TO T LYMPHOCYTES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/051336 International Application No.: PCT/US1998/009057
Publication Date: 19.11.1998 International Filing Date: 04.05.1998
Chapter 2 Demand Filed: 30.10.1998
IPC:
A61K 38/00 (2006.01) ,A61K 47/48 (2006.01) ,C07K 14/05 (2006.01) ,C12N 15/62 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
05
Epstein-Barr virus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
Applicants:
THERATECH, INC. [US/US]; Suite 100 417 Wakara Way Salt Lake City, UT 84108, US
Inventors:
PRAKASH, Ramesh, K.; US
KUMAR, Vijay; US
Agent:
HOWARTH, Alan, J. ; Thorpe, North & Western, LLP P.O. Box 1219 Sandy, UT 84091-1219, US
Priority Data:
08/857,00915.05.1997US
Title (EN) TARGETED DELIVERY TO T LYMPHOCYTES
(FR) ADMINISTRATION CIBLEE VERS DES LYMPHOCYTES T
Abstract:
(EN) A composition for intracellular delivery of a chemical agent into a T cell comprises a receptor-binding and endocytosis-inducing ligand and a chemical agent coupled to a water soluble polymer. The ligand binds to a receptor on T lymphocytes and elicits endocytosis of the composition. The composition also includes a spacer for coupling the chemical agent and the ligand to the polymer. Chemical agents can include cytotoxins, transforming nucleic acids, gene regulators, labels, antigens, drugs, and the like. A preferred water soluble polymer is polyethyleneglycol and activated derivatives thereof. The composition can further comprise a carrier such as a water soluble polymer, liposome, or particulate. Methods of using these compositions for delivering a chemical agent $i(in vivo) or $i(in vitro) are also disclosed.
(FR) Composition servant à administrer par voie intracellulaire un agent chimique vers l'intérieur d'un lymphocyte T et comprenant un ligand de fixation à un récepteur et d'induction de l'endocytose, ainsi qu'un agent chimique couplé à un polymère soluble dans l'eau. Ce ligand se fixe à un récepteur sur les lymphocytes T et déclenche l'endocytose de la composition. Cette composition comprend également un espaceur servant à coupler l'agent chimique et le ligand au polymère. Ces agents chimiques peuvent être, entre autres, des cytotoxines, des acides nucléiques transformants, des régulateurs géniques, des marqueurs, des antigènes ou des médicaments. Un polymère préféré soluble dans l'eau est polyéthylèneglycol et ses dérivés activés. Cette composition peut, de plus, comprendre un véhicule, tel qu'un polymère soluble dans l'eau, un liposome ou des particules. L'invention concerne également des procédés d'utilisation de ces compositions afin d'administrer un agent chimique $i(in vitro) ou $i(in vivo).
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)