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1. (WO1998051335) METHODS OF MODULATING IMMUNE COAGULATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051335 International Application No.: PCT/CA1998/000475
Publication Date: 19.11.1998 International Filing Date: 15.05.1998
Chapter 2 Demand Filed: 10.12.1998
IPC:
A61K 38/00 (2006.01) ,A61K 48/00 (2006.01) ,C07K 16/40 (2006.01) ,C12N 9/64 (2006.01) ,G01N 33/68 (2006.01) ,G01N 33/86 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
64
derived from animal tissue, e.g. rennin
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
86
involving blood coagulating time
Applicants:
TRANSPLANTATION TECHNOLOGIES INC. [CA/CA]; 621 University Avenue, NU10-151 Toronto, M5G 2C4 Ontario, CA (AllExceptUS)
LEVY, Gary [CA/CA]; CA (UsOnly)
CLARK, David, A. [CA/CA]; CA (UsOnly)
Inventors:
LEVY, Gary; CA
CLARK, David, A.; CA
Agent:
BERESKIN & PARR; 40th floor 40 King Street West Toronto, Ontario M5H 3Y2, CA
Priority Data:
60/046,53715.05.1997US
60/061,68410.10.1997US
Title (EN) METHODS OF MODULATING IMMUNE COAGULATION
(FR) METHODES DE MODULATION DE LA COAGULATION IMMUNE
Abstract:
(EN) Methods for mediating immune coagulation using novel antibodies and compounds are described. A protein Fgl2 having direct prothrombinase activity has been identified. Inhibitors of Fgl2 are useful in preventing and treating diseases which require a reduction in immune coagulation including bacterial and viral infections, allograft and xenograft rejection, glomerulonephritis, cancer, a number of gastrointestinal diseases and fetal loss.
(FR) L'invention concerne de nouvelles méthodes permettant d'induire une coagulation immune au moyen de nouveaux anti-corps et composés. On a identifié une protéine Fgl2 ayant une activité prothrombinase directe. Des inhibiteurs de Fgl2 sont utiles dans la prévention et dans le traitement de maladies nécessitant une réduction de la coagulation immune notamment dans les affections bactériennes et virales, le rejet d'allogreffes et d'hétérogreffes, la glomérulonéphrite, le cancer, un certain nombre de maladies gastrointestinales et la perte du foetus.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0975361US6642433US20030099654US20030103974US20050169913JP2001513822
CA2289979AU1998074213