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1. (WO1998051322) CONOPEPTIDES AuIA, AuIB AND AuIC
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051322 International Application No.: PCT/US1998/007004
Publication Date: 19.11.1998 International Filing Date: 09.04.1998
Chapter 2 Demand Filed: 02.11.1998
IPC:
A61K 38/00 (2006.01) ,C07K 7/08 (2006.01) ,C07K 14/435 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
Applicants:
UNIVERSITY OF UTAH RESEARCH FOUNDATION [US/US]; Suite 170 421 Wakara Way Salt Lake City, UT 84108, US
Inventors:
McINTOSH, J., Michael; US
CARTIER, G., Edward; US
YOSHIKAMI, Doju; US
LUO, Siqin; US
OLIVERA, Baldomero, M.; US
Agent:
IHNEN, Jeffrey, L. ; Rothwell, Figg, Ernst & Kurz Suite 701 East 555 13th Street, N.W. Columbia Square Washington, DC 20004, US
Priority Data:
08/857,06815.05.1997US
Title (EN) CONOPEPTIDES AuIA, AuIB AND AuIC
(FR) CONOPEPTIDES AuIA, AuIB, ET AuIC
Abstract:
(EN) This invention relates to relatively short peptides about 14-17 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include two cyclizing disulfide linkages. More specifically, the present invention is directed to conopeptides having the general formula: Gly-Cys-Cys-Ser-Tyr-Xaa1-Xaa1-Cys-Phe-Ala-Thr-Asn-Xaa2-Xaa3-Xaa4-Cys (SEQ ID NO:1), wherein Xaa1 is Pro or Hyp (trans-4-hydroxy-Pro), Xaa2 is Ser, Pro or Hyp, Xaa3 is Gly or Asp and Xaa4 is a Tyr or des- Xaa4. The disulfide bridges are between the first and third between the second fourth cysteine residues. The C-terminal end is preferably amidated. The invention further relates to the specific peptides AuIA: Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phe-Ala-Thr-Asn-Ser-Asp-Tyr-Cys (SEQ ID NO:2); AuIB: Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phe-Ala-Thr-Asn-Pro-Asp-Cys (SEQ ID NO3); and AuIC: Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phe-Ala-Thr-Asn-Ser-Gly-Tyr-Cys (SEQ ID NO:4). The invention also includes pharmaceutically acceptable salts of the conopeptides.
(FR) L'invention porte sur des peptides courts d'une longueur d'environ 14 à 17 résidus se trouvant en quantités infimes dans le venin des escargots ou sur des analogues de peptides naturels comportant deux lignées de bisulfures de cyclisation. L'invention porte plus particulièrement sur des conopeptides de formule générale: Gly-Cys-Cys-Ser-Tyr-Xaa1-Xaa1-Cys-Phé-Ala-Thr-Asn-Xaa2-Xaa3-Xaa3-Xaa4-Cys (SEQ ID NO:1), dans laquelle: Xaa1 est Pro ou Hyp (trans-4-hydroxy-Pro), Xaa2 est Ser, Pro ou Hyp, Xaa3 est Gly ou Asp et Xaa4 est Tyr ou des- Xaa4. Les ponts bisulfure se trouvent entre le premier et le troisième et entre le second et le quatrième résidus de cystéine. L'extrémité C-terminale est de préférence amidée. L'invention porte également sur les peptides spécifiques: AuIA: Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phé-Ala-Thr-Asn-Ser-Asp- Tyr-Cys (SEQ ID NO:2); AuIB: Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phé-Ala-Thr-Asn-Pro-Asp-Cys (SEQ ID NO:3); et AuIC: Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phé-Ala-Thr-Asn-Ser-Gly-Tyr-Cys (SEQ ID NO:4), et sur les sels pharmacocompatibles desdits conopeptides.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998071043