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1. (WO1998051317) OSTEOARTHRITIS CARTILAGE REGENERATION USING HUMAN MESENCHYMAL STEM CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/051317 International Application No.: PCT/US1998/009614
Publication Date: 19.11.1998 International Filing Date: 13.05.1998
Chapter 2 Demand Filed: 10.12.1998
IPC:
A61L 27/38 (2006.01) ,C12N 5/02 (2006.01) ,C12N 5/077 (2010.01) ,C12N 5/0775 (2010.01) ,A61K 35/12 (2006.01) ,A61K 38/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
38
Animal cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
02
Propagation of single cells or cells in suspension; Maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775
Mesenchymal stem cells; Adipose-tissue derived stem cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants: OSIRIS THERAPEUTICS, INC.[US/US]; 2001 Aliceanna Street Baltimore, MD 21231-2001, US
CASE WESTERN RESERVE UNIVERSITY[US/US]; 10900 Euclid Avenue Cleveland, OH 44106-7080, US
Inventors: GOLDBERG, Victor, M.; US
CAPLAN, Arnold, I.; US
BARRY, Francis, P.; US
FINK, David, J.; US
MARSHAK, Daniel, R.; US
BURNS, James, S.; US
Agent: SEMIONOW, Raina ; Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein 6 Becker Farm Road Roseland, NJ 07068, US
Priority Data:
60/047,00213.05.1997US
Title (EN) OSTEOARTHRITIS CARTILAGE REGENERATION USING HUMAN MESENCHYMAL STEM CELLS
(FR) REGENERATION DE CARTILAGE DANS L'ARTHROSE A L'AIDE DE CELLULES SOUCHES MESENCHYMATEUSES HUMAINES
Abstract:
(EN) For repair of cartilage damaged as part of the degenerative effects of osteoarthritis, the inventors have found that the human mesenchymal stem cell approach makes it possible to: 1) regenerate both shallow cartilage chondral defects and full thickness cartilage defects (osteochondral lesions); 2) broaden the suitable clinical population to routinely include middle-aged patients; 3) eliminate the use of autologous tissue grafts (mature cartilage and the periosteal covering) to repair an articular cartilage injury; 4) regenerate other types of injured cartilage such as patellar and spinal disk cartilage; 5) regenerate articular joint cartilage in older patients with osteoarthritis; and 6) form new cartilage and subchondral bone which fully integrate into the adjacent normal tissue.
(FR) La présente invention permet de réparer le cartilage endommagé à la suite des effets dégénératifs de l'arthrose grâce à un procédé faisant appel à des cellules souches mésenchymateuses humaines, lequel procédé permet: (1) de régénérer le cartilage superficiel atteint d'anomalies cartilagineuses ainsi que le cartilage profond atteint d'anomalies telles que des lésions ostéo-cartilagineuses; (2) d'élargir la population clinique indiquée habituelle afin d'y inclure les patients d'âge moyen; (3) d'éviter l'utilisation de greffes de tissus autologues (cartilage mûr et couche périostique) dans la réparation d'une lésion du cartilage articulaire; (4) de régénérer d'autres types de cartilage atteint tel que le cartilage de la rotule et du disque spinal; (5) de régénérer le cartilage des articulations chez les patients âgés souffrant d'arthrose; et (6) de former un nouveau cartilage et os sous-chondral qui s'intègrent parfaitement dans les tissus normaux adjacents.
Designated States: AU, CA, JP
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)