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1. (WO1998051311) DIHYDROPYRIMIDINES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/051311 International Application No.: PCT/US1998/010082
Publication Date: 19.11.1998 International Filing Date: 15.05.1998
Chapter 2 Demand Filed: 04.12.1998
IPC:
C07D 239/22 (2006.01) ,C07D 401/12 (2006.01) ,C07D 401/14 (2006.01) ,C07D 405/14 (2006.01) ,C07D 409/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
20
having two double bonds between ring members or between ring members and non-ring members
22
with hetero atoms directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
Applicants:
SYNAPTIC PHARMACEUTICAL CORPORATION [US/US]; 215 College Road Paramus, NJ 07652, US
Inventors:
WONG, Wai, C.; US
LAGU, Bharat; US
NAGARATHNAM, Dhanapalan; US
MARZABADI, Mohammad, R.; US
GLUCHOWSKI, Charles; US
Agent:
WHITE, John, P.; Cooper & Dunham LLP 1185 Avenue of the Americas New York, NY 10036, US
Priority Data:
08/858,01716.05.1997US
Title (EN) DIHYDROPYRIMIDINES AND USES THEREOF
(FR) DIHYDROPYRIMIDINES ET LEURS UTILISATIONS
Abstract:
(EN) This invention is directed to dihydropyrimidine compounds which are selective antagonists for human $g(a)1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the $g(a)1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.
(FR) L'invention concerne des composés de dihydropyrimidine constituant des antagonistes sélectifs des récepteurs humains $g(a)1A. Cette invention concerne également des utilisations de ces composés, visant à réduire la tension intraoculaire, à inhiber la synthèse du cholestérol, à détendre les tissus des voies urinaires inférieures, et à traiter l'hyperplasie prostatique bénigne, l'impuissance, et l'arythmie cardiaque. Ces composés peuvent également être utilisés pour traiter toute maladie où l'antagonisme dudit récepteur humain $g(a)1A peut être utile. L'invention concerne enfin une composition pharmaceutique renfermant une quantité thérapeutiquement efficace des composés susmentionnés, ainsi qu'un porteur pharmaceutiquement acceptable.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)