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1. (WO1998051299) PATCHES CONTAINING ISOSORBIDE NITRATE

Pub. No.:    WO/1998/051299    International Application No.:    PCT/JP1998/002062
Publication Date: Fri Nov 20 00:59:59 CET 1998 International Filing Date: Tue May 12 01:59:59 CEST 1998
IPC: A61K 9/70
A61K 31/34
A61K 47/32
Applicants: TEIKOKU SEIYAKU CO., LTD.

KAWAJI, Toshikuni

YAMAJI, Masahiro

Inventors: KAWAJI, Toshikuni

YAMAJI, Masahiro

Title: PATCHES CONTAINING ISOSORBIDE NITRATE
Abstract:
Patches containing isosorbide nitrate, having sufficient tackiness in the application thereof, and stabilized in the release of the drug after the application. The patches are characterized in that isosorbide nitrate is added as the active ingredient to tacky plasters containing as the essential ingredients styrene-isoprene-styrene block copolymers, rosin resins, liquid rubbers, antioxidants and oleic acid. More particularly, 15 to 25 % (w/w) of isosorbide nitrate is added to plasters containing 15 to 35 % of styrene-isoprene-styrene block copolymers, 35 to 55 % of rosin resins, 5 to 20 % of liquid rubbers, 0.1 to 2 % of antioxidants and 0.1 to 5 % of oleic acid.