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1. (WO1998051298) ARYLSUBSTITUTED PIPERAZINES USEFUL IN THE TREATEMENT OF BENIGN PROSTATIC HYPERLASIA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051298 International Application No.: PCT/US1998/009023
Publication Date: 19.11.1998 International Filing Date: 08.05.1998
Chapter 2 Demand Filed: 11.12.1998
IPC:
C07D 207/27 (2006.01) ,C07D 207/28 (2006.01) ,C07D 209/48 (2006.01) ,C07D 211/76 (2006.01) ,C07D 223/10 (2006.01) ,C07D 295/13 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18
having one double bond between ring members or between a ring member and a non-ring member
22
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24
Oxygen or sulfur atoms
26
2-Pyrrolidones
263
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
27
with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18
having one double bond between ring members or between a ring member and a non-ring member
22
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24
Oxygen or sulfur atoms
26
2-Pyrrolidones
273
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
277
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
28
2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
44
Iso-indoles; Hydrogenated iso-indoles
48
with oxygen atoms in positions 1 and 3, e.g. phthalimide
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68
having one double bond between ring members or between a ring member and a non-ring member
72
with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
74
Oxygen atoms
76
attached in position 2 or 6
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
223
Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
02
not condensed with other rings
06
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
08
Oxygen atoms
10
attached in position 2
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04
with substituted hydrocarbon radicals attached to ring nitrogen atoms
12
substituted by singly or doubly bound nitrogen atoms
125
with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
13
to an acyclic saturated chain
Applicants:
ORTHO-McNEIL PHARMACEUTICAL INC. [US/US]; U.S. Route 202 Raritan, NJ 08869-0602, US
Inventors:
JOLLIFFE, Linda; US
MURRAY, William; US
PULITO, Virginia; US
REITZ, Alan; US
LI, Xiaobing; US
MULCAHY, Linda; US
MARYANOFF, Cynthia; US
VILLANI, Frank; US
Agent:
CIAMPORCERO, Audley, A., Jr. ; Johnson & Johnson One Johnson & Johnson Plaza New Brunswick, NJ 08933, US
Priority Data:
60/046,23612.05.1997US
Title (EN) ARYLSUBSTITUTED PIPERAZINES USEFUL IN THE TREATEMENT OF BENIGN PROSTATIC HYPERLASIA
(FR) PIPERAZINES A SUBSTITUTION ARYLE UTILES DANS LE TRAITEMENT DE L'ADENOME PROSTATIQUE
Abstract:
(EN) This invention relates to a series of arylsubstituted piperazines, of Formula (I), pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the $g(a)-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
(FR) L'invention concerne une série de pipérazines à substitution aryle, de formule (I) et des compositions pharmaceutiques renfermant ces pipérazines ainsi que des intermédiaires utilisés dans leur élaboration. Les composés décrits inhibent de manière sélective la liaison sur adrénorécepteur $g(a)-1a, un récepteur intervenant dans l'adénome prostatique. En tant que tels, lesdits composés ont une utilité potentielle dans le traitement de l'adénome considéré et d'autres affections.
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Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1999-3997NO19995518TR1999/02971MXPA/a/1999/010518APAP 1349KR1020010012505
SG68884IL132836BRPI9809804EP0984777US6303594US6593474
US20030220493JP2002511065 CN1264300CN1515556CN1515563CA2289987
EA199900928NZ500992DK0984777AU1998073669AU2002300904MYPI 20041438
MYPI 98002108