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1. (WO1998051295) HIV-1 PROTEASE INHIBITORS, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051295 International Application No.: PCT/JP1998/002059
Publication Date: 19.11.1998 International Filing Date: 11.05.1998
IPC:
A61K 38/00 (2006.01) ,C07K 14/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
15
Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155
Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16
HIV-1
Applicants:
NISSUI PHARMACEUTICAL CO., LTD. [JP/JP]; 11-1, Sugamo 2-chome Toshima-ku Tokyo 170-0002, JP (AllExceptUS)
SHOUJI, Shouzou [JP/JP]; JP (UsOnly)
Inventors:
SHOUJI, Shouzou; JP
Agent:
MITSUKUDE, Yoshihiko; T-Kanai Building 2-1, Kanda-awajicho Chiyoda-ku Tokyo 101-0063, JP
Priority Data:
9/13937214.05.1997JP
Title (EN) HIV-1 PROTEASE INHIBITORS, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITIONS
(FR) INHIBITEUR DE LA PROTEASE DU VIH-1, LEUR PROCEDE DE PRODUCTION, ET COMPOSITIONS MEDICINALES
Abstract:
(EN) HIV-1 protease inhibitors, each containing as the active ingredient a P2 peptide which is a peptide translated from the gene information of HIV-1 virus. The inhibitors contain each as the active ingredient a synthetic peptide having the same amino acid sequence as that of the P2 peptide or compounds analogous to the P2 peptide. These HIV-1 protease inhibitors are based on methionine-containing compounds which are particularly exemplified by peptides having the amino acid sequence Ala-Glu-Ala-Met-Ser-Gln-Val-Thr-Asn-Thr-Ala-Thr-Ile-Met.
(FR) Inhibiteurs de la protéase du VIH-1, contenant chacun, comme principe actif, un peptide P2 qui est un peptide traduit de l'information génique du virus VIH-1. Lesdits inhibiteurs contiennent chacun, comme principe actif, un peptide synthétique ayant la même séquence d'acides aminés que celle du peptide P2 ou de composés analogues à ce dernier. Ces inhibiteurs de la protéase du VIH-1 sont à base de composés contenant de la méthionine qui sont particulièrement représentés par des peptides ayant la séquence d'acides aminés Ala-Glu-Ala-Met-Ser-Gln-Val-Thr-Asn-Thr-Ala-Thr-Ile-Met.
Designated States: CA, JP, KR, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
KR1020000022426EP0922455CA2259425